Document Detail

Hypoxic respiratory failure: etiology and outcomes at one referral center 2000 through 2005.
MedLine Citation:
PMID:  17443197     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We calculated in a referral population of term and near-term infants with hypoxic respiratory failure (HRF) as a primary presenting problem the overall survival rate, the need for extracorporeal membrane oxygenation (ECMO) and the incidence of apparently irreversible disorders. STUDY DESIGN: All infants >or=36-week gestation admitted at <or=72 h of age from 2000 through 2005 were identified. The worst (highest) oxygen index (OI) was calculated and outcomes were noted. RESULTS: A total of 630 infants were reviewed and 315 infants were identified with primary diagnosis of HRF; four infants died before discharge. One hundred seventy-seven infants had OI <or=14; 71 had OI of 15 to 25; and 67 had OI of >25. A total of 32 infants received ECMO, including all four who died, two with histologic evidence of pulmonary malformations and two with septic shock. CONCLUSION: Term or near-term infants with isolated HRF are likely to survive, given the low incidence of pulmonary disorders not supportable by inhaled nitric oxide or ECMO.
W E Truog; G Kurth; B Haney; H W Kilbride
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-19
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  27     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-24     Completed Date:  2007-07-20     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Children's Mercy Hospitals and Clinics, Department of Pediatrics, Section of Neonatology, Kansas City, MO 64108, USA.
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MeSH Terms
Administration, Inhalation
Extracorporeal Membrane Oxygenation / utilization
Fetal Hypoxia / blood,  epidemiology*,  etiology,  therapy
Infant, Newborn
Intensive Care Units
Medical Records
Missouri / epidemiology
Nitric Oxide / administration & dosage
Oxygen / blood*
Referral and Consultation / statistics & numerical data
Respiratory Insufficiency / blood,  complications,  epidemiology*,  therapy
Retrospective Studies
Grant Support
R-01 70560//PHS HHS
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7782-44-7/Oxygen

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