Document Detail


Hypoxic pulmonary vasoconstriction persists in the human transplanted lung.
MedLine Citation:
PMID:  3545645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preservation of hypoxic pulmonary vasoconstriction (HPV) in the denervated lung was studied in five human heart-lung transplant recipients. All five patients showed significant increases in mean pulmonary artery pressure and pulmonary vascular resistance during hypoxic exposure, returning toward normoxic values during recovery. Aside from PAO2 and Pao2, other factors known to influence pulmonary vascular resistance did not change significantly during the hypoxic period. There was no relation between the length of the post-transplantation period and the intensity of HPV, suggesting that reinnervation of the pulmonary vascular bed did not account for persistent HPV and that HPV persists in the human transplanted lung despite the loss of autonomic neural innervation.
Authors:
E D Robin; J Theodore; C M Burke; S N Oesterle; M B Fowler; S W Jamieson; J C Baldwin; A J Morris; S A Hunt; A Vankessel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  72     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-04-20     Completed Date:  1987-04-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / physiopathology*
Autonomic Nervous System
Heart Transplantation
Humans
Lung / blood supply*,  innervation
Lung Transplantation
Regional Blood Flow
Vascular Resistance
Vasoconstriction*
Grant Support
ID/Acronym/Agency:
H13108//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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