| Hypoxic pulmonary vasoconstriction in pigs: role of endothelin-1, prostanoids and ATP-dependent potassium channels. | |
| | |
MedLine Citation:
|
PMID: 9774177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study investigated the mechanisms that may contribute to the hypoxic pulmonary vasoconstriction and compared the effects of hypoxia on pulmonary and systemic vascular beds. Six anesthetized spontaneously breathing pigs inhaled a hypoxic mixture (10% O2 in air) in control conditions and after pre-treatment with Indomethacin (3 mg kg(-1) i.v.) to block the cyclooxygenase pathway. During hypoxia, the Indomethacin pre-treated pigs were given Cromakalim (80 microg kg(-1) i.v.) to activate K+(ATP) channels. Bosentan (5 mg kg(-1) i.v.) was administered to block endothelin-1 receptors and then during hypoxia Cromakalim was administered as before. In all experimental conditions we recorded breathing pattern and vascular parameters: mean systemic and pulmonary arterial pressures; systemic and pulmonary vascular resistances; cardiac output; and heart rate. Vascular and respiratory responses to hypoxia were determined when PaO2 was reduced to 50 +/- 5 mmHg. The main finding was that in spontaneously breathing pigs, hypoxia induces pulmonary vasoconstriction and an increase in mean systemic arterial pressure, which are cyclooxygenase-independent. A role of endothelin-1 appears in both vascular districts, but pulmonary vasoconstriction may also be due to ET-1-dependent inhibition of K+(ATP) channels. |
| | |
Authors:
|
M Albertini; M G Clement |
Related Documents
:
|
241107 - Cerebrospinal fluid alkalosis during high-altitude sojourn in unanesthetized ponies. 6050107 - Effect of progressive hypoxia on the respiratory & cardiovascular system of chickens. 3249307 - Myocardial performance and free energy of atp-hydrolysis in isolated rat hearts during ... 10472127 - Influence of noradrenaline on the respiratory status of rana balcanica red cell suspens... 6205587 - Safety and efficacy of continuous intravenous morphine for severe cancer pain. 2457767 - Hemodynamic effects of alpha-human atrial natriuretic peptide in healthy volunteers. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 59 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 1998 Aug |
Date Detail:
|
Created Date: 1998-12-09 Completed Date: 1998-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: SCOTLAND |
Other Details:
|
Languages: eng Pagination: 137-42 Citation Subset: IM |
Affiliation:
|
Istituto di Fisiologia Veterinaria e Biochimica, Università di Milano, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenosine Triphosphate
/
metabolism Animals Anoxia / physiopathology* Antihypertensive Agents / pharmacology Blood Pressure Cardiac Output Cromakalim / pharmacology Cyclooxygenase Inhibitors / pharmacology Endothelin-1 / antagonists & inhibitors, physiology* Female Heart Rate Indomethacin / pharmacology Male Potassium Channels / physiology* Pulmonary Artery / physiopathology* Pulmonary Ventilation Sulfonamides / pharmacology Swine Vascular Resistance Vasoconstriction / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Cyclooxygenase Inhibitors; 0/Endothelin-1; 0/Potassium Channels; 0/Sulfonamides; 147536-97-8/bosentan; 53-86-1/Indomethacin; 56-65-5/Adenosine Triphosphate; 94470-67-4/Cromakalim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Attenuation of oxidant-mediated endothelial cell injury with docosahexaenoic acid: the role of intra...
Next Document: Influence of long-chain polyunsaturated fatty acids on oxidation of low density lipoprotein.