Document Detail

Hypoxic pulmonary vasoconstriction in pigs: role of endothelin-1, prostanoids and ATP-dependent potassium channels.
MedLine Citation:
PMID:  9774177     Owner:  NLM     Status:  MEDLINE    
This study investigated the mechanisms that may contribute to the hypoxic pulmonary vasoconstriction and compared the effects of hypoxia on pulmonary and systemic vascular beds. Six anesthetized spontaneously breathing pigs inhaled a hypoxic mixture (10% O2 in air) in control conditions and after pre-treatment with Indomethacin (3 mg kg(-1) i.v.) to block the cyclooxygenase pathway. During hypoxia, the Indomethacin pre-treated pigs were given Cromakalim (80 microg kg(-1) i.v.) to activate K+(ATP) channels. Bosentan (5 mg kg(-1) i.v.) was administered to block endothelin-1 receptors and then during hypoxia Cromakalim was administered as before. In all experimental conditions we recorded breathing pattern and vascular parameters: mean systemic and pulmonary arterial pressures; systemic and pulmonary vascular resistances; cardiac output; and heart rate. Vascular and respiratory responses to hypoxia were determined when PaO2 was reduced to 50 +/- 5 mmHg. The main finding was that in spontaneously breathing pigs, hypoxia induces pulmonary vasoconstriction and an increase in mean systemic arterial pressure, which are cyclooxygenase-independent. A role of endothelin-1 appears in both vascular districts, but pulmonary vasoconstriction may also be due to ET-1-dependent inhibition of K+(ATP) channels.
M Albertini; M G Clement
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  59     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-12-09     Completed Date:  1998-12-09     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Istituto di Fisiologia Veterinaria e Biochimica, Università di Milano, Italy.
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MeSH Terms
Adenosine Triphosphate / metabolism
Anoxia / physiopathology*
Antihypertensive Agents / pharmacology
Blood Pressure
Cardiac Output
Cromakalim / pharmacology
Cyclooxygenase Inhibitors / pharmacology
Endothelin-1 / antagonists & inhibitors,  physiology*
Heart Rate
Indomethacin / pharmacology
Potassium Channels / physiology*
Pulmonary Artery / physiopathology*
Pulmonary Ventilation
Sulfonamides / pharmacology
Vascular Resistance
Vasoconstriction / physiology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Cyclooxygenase Inhibitors; 0/Endothelin-1; 0/Potassium Channels; 0/Sulfonamides; 53-86-1/Indomethacin; 56-65-5/Adenosine Triphosphate; 94470-67-4/Cromakalim; Q326023R30/bosentan

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