Document Detail

Hypoxic pressor response, cardiac size, and natriuretic peptides are modified by long-term intermittent hypoxia.
MedLine Citation:
PMID:  10601145     Owner:  NLM     Status:  MEDLINE    
We investigated whether the effect of long-term intermittent hypoxia (LTIH) on cardiovascular function may be modified by preexisting genetic traits. To induce LTIH experimentally, cycles of 90-s hypoxia (nadir 6%) followed by 90-s normoxia were applied to six Wistar-Kyoto and six spontaneously hypertensive rats during 8 h daily. Comparison with the same number of control animals after 70 days revealed no alteration of intra-arterial blood pressure or heart rate. Blood pressure responsiveness to a brief hypoxic stimulus was enhanced in the LTIH animals, regardless of strain, whereas the hypoxia-induced increase in heart rate was abolished. In the spontaneously hypertensive but not the Wistar-Kyoto rats, LTIH increased left ventricular weight-to-body weight ratio and content of atrial natriuretic peptide mRNA. Expression of B-type natriuretic peptide was unchanged (Northern blot). Slightly increased right ventricular weight-to-body weight ratios in the LTIH animals were associated with higher right ventricular atrial natriuretic peptide and B-type natriuretic peptide mRNA amounts. Consequently, the effects of LTIH on different components of cardiovascular function appear incompletely related to each other and differentially influenced by constitutional traits.
H Kraiczi; J Magga; X Y Sun; H Ruskoaho; X Zhao; J Hedner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  87     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-03     Completed Date:  2000-02-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2025-31     Citation Subset:  IM; S    
Department of Clinical Pharmacology, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden.
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MeSH Terms
Anoxia / metabolism,  pathology*,  physiopathology*
Atrial Natriuretic Factor / genetics,  metabolism*
Blood Pressure*
Chronic Disease
Heart Ventricles
Myocardium / metabolism,  pathology*
Natriuretic Peptide, Brain
Organ Size
RNA, Messenger / metabolism
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:
0/RNA, Messenger; 114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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