Document Detail


Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity.
MedLine Citation:
PMID:  14561784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to investigate whether the mean around which arterial oxygen fluctuations take place was important in a unique animal model of oxygen-induced retinopathy. Retinopathy of prematurity (ROP) is associated with fluctuating arterial oxygen. A recent retrospective study suggested that management of high-risk preterm infants at lower oxygen saturations was associated with less severe ROP. Rat pups were raised in a variable oxygen environment around a high (24%), normal (21%) or low (17%) mean inspired oxygen for 14 d. Rat pups raised in the high (24%) mean variable oxygen environment had more retarded retinal vascular development than did rats raised in an environment that fluctuated around 21% mean oxygen. In contrast, rats raised in a lower mean (17%) but still variable oxygen environment had no discernible retinal differences from controls raised in constant room air. Rats raised in a relatively hypoxic but variable oxygen environment develop less severe retinal vascular abnormalities than those raised in variable oxygen around higher oxygen means.
Authors:
Janet R McColm; Steve Cunningham; Jean Wade; Kofi Sedowofia; Balazs Gellen; Tarun Sharma; Neil McIntosh; Brian W Fleck
Related Documents :
658174 - Hemoglobinemia in rats exposed to high altitude.
6402954 - Effects of halothane, isoflurane, enflurane, thiopental, and fentanyl on blood gas valu...
2921294 - Mechanisms of cerebrovascular o2 sensitivity from hyperoxia to moderate hypoxia in the ...
3372424 - Carotid body excision significantly changes ventilatory control in awake rats.
1998744 - Effects of hyperthyroidism on synthesis, secretion and metabolism of the vldl apoprotei...
11039474 - Long-term effects of nafamostat and imipenem on experimental acute pancreatitis in rats.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-10-15
Journal Detail:
Title:  Pediatric research     Volume:  55     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  107-13     Citation Subset:  IM    
Affiliation:
Child Life and Health, Reproductive and Developmental Sciences, University of Edinburgh, Edingurgh, United Kingdom. jmccolm@email.unc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / complications*,  metabolism*,  pathology
Body Weight
Capillaries / pathology
Disease Models, Animal
Humans
Hyperoxia / complications*,  metabolism*,  pathology
Immunohistochemistry
Infant, Newborn
Lectins
Rats
Retina / metabolism,  pathology
Retinal Vessels / pathology
Retinopathy of Prematurity / etiology*,  metabolism*,  pathology
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Lectins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effects of systemic magnesium sulfate infusion on brain magnesium concentrations and energy stat...
Next Document:  Bone marrow stroma damage induced by chemotherapy for acute lymphoblastic leukemia in children.