| Hypoxic and nycthemeral responses by the adrenal cortex of partially hepatectomized rats. | |
| | |
MedLine Citation:
|
PMID: 6466249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Adrenocortical nycthemeral (day-night alteration) and hypoxic stress responses of rats were evaluated 48 h following 70% hepatectomy. Morning plasma and adrenal corticosterone concentrations of hepatectomized (H) rats at 0800 hours were significantly higher than those of sham (S) operated animals. Although both groups showed significant nocturnal elevations in these parameters at 2000 hours, the nocturnal rises in plasma corticosterone levels were 75% and 223% in H and S rats, respectively, yet the absolute steroid levels did not differ between the groups. The hypothalamic-pituitary-adrenocortical (HPA) response of H animals to hypoxia was assessed by measuring plasma corticosterone levels at various times before, during and after exposure to 10% O2 at ground level. Curvilinear analysis of the plasma steroid levels revealed a significantly slower corticosterone rise during the hypoxic phase in H than S animals, as well as a much slower return to baseline levels after the hypoxic stimulus was terminated. The latter indicates a decreased hepatic capacity to inactivate steroids in H animals, while the sluggish activation of the HPA system by hypoxia may be due to altered neuroendocrine control resulting from prior exposure of feedback sites to elevated basal plasma corticosterone levels. |
| | |
Authors:
|
L Witek-Janusek; M Yu; S F Marotta |
Related Documents
:
|
3196439 - Plasma corticosterone fluctuations in an infant-learning paradigm. 495129 - Effect of testosterone and thyroxine on corticosterone and transcortine plasma levels i... 2388339 - Adrenal adenoma with excess secretion of corticosterone and 18-hydroxycorticosterone. 478439 - Adenohypophyseal hormone response to chronic stress in dexamethasone-treated rats. 20839989 - Effect of a synthetic appeasing pheromone on behavioral, neuroendocrine, immune, and ac... 6489739 - Variations in aldosterone and corticosterone plasma levels during metamorphosis in xeno... 1319009 - Pulsatile acth and cortisol in goats: effects of insulin-induced hypoglycemia and dexam... 20043259 - The effects of storage time and sampling season on the stability of serum 25-hydroxy vi... 1528299 - Epidermal growth factor (egf) in serum of patients with differentiated carcinoma of thy... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Aviation, space, and environmental medicine Volume: 55 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 1984 Jun |
Date Detail:
|
Created Date: 1984-09-11 Completed Date: 1984-09-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 538-41 Citation Subset: IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Cortex
/
metabolism,
physiopathology* Animals Anoxia / physiopathology* Circadian Rhythm Corticosterone / blood, metabolism Hepatectomy* Hypothalamo-Hypophyseal System / physiopathology Male Organ Size Pituitary-Adrenal System / physiopathology Rats |
| Grant Support | |
ID/Acronym/Agency:
|
PHS-NU-05005/NU/BHP HRSA HHS |
| Chemical | |
Reg. No./Substance:
|
50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Motion sickness incidence: distribution of time to first emesis and comparison of some complex motio...
Next Document: Impairment of thermogenesis and heat conservation in rats during 3 hours of 3-G exposure.