Document Detail

Hypoxic-ischemic brain injury and the vegetative state: clinical and neuropathologic correlation.
MedLine Citation:
PMID:  7196525     Owner:  NLM     Status:  MEDLINE    
We studied 10 patients who survived for 2 to 8 weeks in a vegetative state, including 8 with cardiopulmonary failure and 2 with subarachnoid hemorrhage. Within days of onset, they regained brainstem function and awoke, but none had evidence of cognitive awareness. All patients opened their eyes within 2 weeks, and eight had roving conjugate eye movements. Pupillary and corneal responses were intact within 1 week, and seven patients had tonic oculovestibular responses (OVR) within 24 hours. By the end of 1 day, only three patients failed to move limbs in response to noxious stimuli. At postmortem, all patients had widespread ischemic neuronal damage in the cerebral hemispheres. The brainstems lacked morphologic abnormality, except that one patient had a single microinfarct in the superior colliculus.
J H Dougherty; D G Rawlinson; D E Levy; F Plum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  31     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  991-7     Citation Subset:  AIM; IM    
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MeSH Terms
Brain / pathology*
Brain Stem / pathology,  physiopathology
Cerebellum / pathology
Cerebral Cortex / pathology
Coma / diagnosis,  pathology*,  physiopathology
Eye Movements
Hippocampus / pathology
Middle Aged
Thalamus / pathology
Grant Support

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