| Hypoxic exercise training reduces senescent T-lymphocyte subsets in blood. | |
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MedLine Citation:
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PMID: 20884344 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The integration and control of systemic immune responses depends on the regulated trafficking of T-lymphocytes. This study elucidates how various exercises regimens with/without hypoxia affect phenotypic characteristics of T-lymphocyte subsets in blood. Fifty sedentary males were randomly divided into five groups. Each group (n=10) received one of five interventions: normoxic (21%O(2)) resting (N-C), hypoxic (15%O(2)) resting (H-C), normoxic exercise (50%W(max) under 21%O(2), N-T), hypoxic-relative exercise (50% maximal heart rate reserve under 15%O(2), H-RT), or hypoxic-absolute exercise (50%W(max) under 15%O(2), H-AT) for 30min/day, 5days/week for 4weeks. Before the intervention, strenuous exercise up to exhaustion increased the mobilization of CD3, CD4, CD8, or CD8(bright) lymphocytes expressing activated (CD11a) or senescent (KLRG1) molecules into the peripheral blood compartment. The H-AT for 4weeks up-regulated co-stimulatory molecule CD28 expression and was accompanied by depressed KLRG1 level on CD3, CD4, CD8, or CD8(bright) lymphocytes at rest or following exercise. Simultaneously, this intervention increased interferon-γ (IFN-γ) level and unchanged interleukin-4 level, as well as, decreased myeloperoxidase (MPO) and interleukin-6 levels in plasma. However, no significant changes in resting and exercise-induced mobilizations of various T-lymphocyte subsets and productions of cytokines and MPO occurred following the N-C, H-C, N-T, and H-RT interventions. Therefore, we conclude that 4-week H-AT intervention reduced senescent T-lymphocyte subsets with increasing IFN-γ level in blood, which responses are accompanied by depressed oxidative stress and pro-inflammatory cytokine production. These findings can help to determine an effective hypoxic exercise regimen to minimize immune dysfunction by retarding T-lymphocyte senescence. |
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Authors:
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Jong-Shyan Wang; Wan-Ling Chen; Tzu-Pin Weng |
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Publication Detail:
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Type: Journal Article Date: 2010-09-25 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 25 ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 270-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Graduate Institute of Rehabilitation Science, Chang Gung University, Tao-Yuan 333, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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