Document Detail

Hypoxic Vasospasm Mediated by cIMP : When Soluble Guanylyl Cyclase Turns Bad.
MedLine Citation:
PMID:  25264755     Owner:  NLM     Status:  Publisher    
In a number of isolated blood vessel types hypoxia causes an acute contraction that is dependent on the presence of nitric oxide (NO) and activation of soluble guanylyl cyclase (sGC). It is more pronounced when the preparations are constricted and is therefore termed hypoxic augmentation of vasoconstriction. This hypoxic response is accompanied by increases in the intracellular level of inosine 5'-triphosphate (ITP) and in the synthesis of inosine 3',5'-cyclic monophosphate (cIMP) by sGC. The administration of exogenous cIMP or ITP causes augmented vasoconstriction to hypoxia. Furthermore, the vasoconstriction evoked by hypoxia and cIMP is associated with increased activity of Rho kinase (ROCK), indicating that cIMP may mediate the hypoxic effect by sensitizing the myofilaments to Ca via ROCK. Hypoxia is implicated in exaggerated vasoconstriction in the pathogenesis of coronary artery disease, myocardial infarction, hypertension and stroke. The newly found role of cIMP may help to identify unique therapeutic targets for certain cardiovascular disorders.
Yuansheng Gao; Zhengju Chen; Leung Sws; Paul M Vanhoutte
Related Documents :
10359735 - Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis ...
21536015 - Ppar-γ and ampk - advantageous targets for myocardial ischemia/reperfusion therapy.
19802535 - Influence of shengmai capsule on recovery of living capacity in patients after myocardi...
11716325 - Effects of valsalva maneuver on qt dispersion in patients with ischemic heart diseases.
7357715 - Symptom-limited vs heart-rate-limited exercise testing soon after myocardial infarction.
18375595 - Controlling ischemic cardiovascular disease: from basic mechanisms to clinical management.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-26
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-29     Completed Date:  -     Revised Date:  2014-9-30    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nuclear Compartmentalization of ?1-Adrenergic Receptor Signaling in Adult Cardiac Myocytes.
Next Document:  Efficacy and safety of perioperative sodium bicarbonate therapy for cardiac surgery-associated acute...