Document Detail


Hypoxic Pulmonary Vasoconstriction.
MedLine Citation:
PMID:  23795729     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Swenson, Erik R. Hypoxic pulmonary vasoconstriction. High Alt Med Biol 14:101-110, 2013.-Hypoxic pulmonary vasoconstriction (HPV) continues to fascinate cardiopulmonary physiologists and clinicians since its definitive description in 1946. Hypoxic vasoconstriction exists in all vertebrate gas exchanging organs. This fundamental response of the pulmonary vasculature in air breathing animals has relevance to successful fetal transition to air breathing at birth and as a mechanism of ventilation-perfusion matching in health and disease. It is a complex process intrinsic to the vascular smooth muscle, but with in vivo modulation by a host of factors including the vascular endothelium, erythrocytes, pulmonary innervation, circulating hormones and acid-base status to name only a few. This review will provide a broad overview of HPV and its mechansms and discuss the advantages and disadvantages of HPV in normal physiology, disease and high altitude.
Authors:
Erik R Swenson
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  14     ISSN:  1557-8682     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  101-110     Citation Subset:  -    
Affiliation:
Departments of Medicine and of Physiology and Biophysics, University of Washington , VA Puget Sound Health Care System, Seattle, Washington.
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