Document Detail

Hypoxic Ischemic Encephalopathy: Pathophysiology and Experimental Treatments.
MedLine Citation:
PMID:  21927583     Owner:  NLM     Status:  Publisher    
Hypoxic ischemic encephalopathy (HIE) is a serious birth complication affecting full term infants: 40-60% of affected infants die by 2 years of age or have severe disabilities. The majority of the underlying pathologic events of HIE are a result of impaired cerebral blood flow and oxygen delivery to the brain with resulting primary and secondary energy failure. In the past, treatment options were limited to supportive medical therapy. Currently, several experimental treatments are being explored in neonates and animal models to ameliorate the effects of secondary energy failure. This review discusses the underlying pathophysiologic effects of a hypoxic-ischemic event and experimental treatment modalities being explored to manage infants with HIE. Further research is needed to better understand if the long-term impact of the experimental treatments and whether the combinations of experimental treatments can improve outcomes in infants with HIE.
Kimberly A Allen; Debra H Brandon
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Publication Detail:
Journal Detail:
Title:  Newborn and infant nursing reviews : NAINR     Volume:  11     ISSN:  1558-352X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126037     Medline TA:  Newborn Infant Nurs Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  125-133     Citation Subset:  -    
Duke University School of Nursing, DUMC 3322, 307 Trent Drive, Durham, NC 27710.
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Grant Support
F31 NR012083-01//NINR NIH HHS

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