| Hypoxic Exercise Training Causes Erythrocyte Senescence and Rheological Dysfunction by Depressed Gardos Channel Activity. | |
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MedLine Citation:
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PMID: 21551009 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Despite enhancing cardiopulmonary and muscular fitness, the effect of hypoxic exercise training (HE) on hemorheological regulation remains unclear. This study investigates how HE modulates erythrocyte rheological properties, and further explores the underlying mechanisms in the hemorheological alterations. Twenty four sedentary males were randomly divided into hypoxic (HE, n=12) and normoxic (NE, n=12) exercise training groups. The subjects were trained on 60% of maximum work-rate under 15% (HE) or 21% (NE) O(2) condition for 30 minutes daily, 5 days weekly for 5 weeks. The results demonstrated that HE (i) down-regulated CD47 and CD147expressions on erythrocyte, (ii) decreased actin and spectrin contents in erythrocyte, (iii) reduced erythrocyte deformability under shear flow, and (iv) diminished erythrocyte volume changed by hypotonic stress. Treatment of erythrocytes with H(2)O(2) that mimicked in vivo pro-oxidative status resulted in the cell shrinkage, rigidity, and phosphatidylserine exposure, whereas HE enhanced the eryptotic responses to H(2)O(2). However, HE decreased the degrees of clotrimazole to blunt ionomycin-induced shrinkage, rigidity, and cytoskeleton breakdown of erythrocytes, referred to as Gardos effects. Reduced erythrocyte deformability by H(2)O(2) was inversely related to the erythrocyte Gardos effect on the rheological function. Conversely, NE intervention did not significantly change resting and exercise erythrocyte rheological properties. Therefore, we conclude that HE rather than NE reduces erythrocyte deformability and volume regulation, accompanied by an increase in the eryptotic response to oxidative stress. Simultaneously, this intervention depresses Gardos channel-modulated erythrocyte rheological functions. Results of this study provide further insight into erythrocyte senescence induced by HE. |
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Authors:
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Tso-Yen Mao; Li-Lan Fu; Jong-Shyan Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-5 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1National Taiwan Sport University. |
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