Document Detail

Hypoxia triggers meiotic fate acquisition in maize.
MedLine Citation:
PMID:  22822150     Owner:  NLM     Status:  MEDLINE    
Evidence from confocal microscopic reconstruction of maize anther development in fertile, mac1 (excess germ cells), and msca1 (no germ cells) flowers indicates that the male germ line is multiclonal and uses the MAC1 protein to organize the somatic niche. Furthermore, we identified redox status as a determinant of germ cell fate, defining a mechanism distinct from the animal germ cell lineage. Decreasing oxygen or H(2)O(2) increases germ cell numbers, stimulates superficial germ cell formation, and rescues germinal differentiation in msca1 flowers. Conversely, oxidizing environments inhibit germ cell specification and cause ectopic differentiation in deeper tissues. We propose that hypoxia, arising naturally within growing anther tissue, acts as a positional cue to set germ cell fate.
Timothy Kelliher; Virginia Walbot
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  337     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-23     Completed Date:  2012-08-02     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-8     Citation Subset:  IM    
Data Bank Information
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MeSH Terms
Cell Hypoxia
Cells, Cultured
Germ Cells / metabolism
Oxygen / metabolism*,  pharmacology
Plant Epidermis / cytology,  drug effects,  metabolism
Water / metabolism,  pharmacology
Zea mays / cytology*,  drug effects,  genetics*
Grant Support
5-T32-GM008412-17/GM/NIGMS NIH HHS; T32 GM008412/GM/NIGMS NIH HHS
Reg. No./Substance:
059QF0KO0R/Water; S88TT14065/Oxygen
Comment In:
Nat Rev Genet. 2012 Sep;13(9):596   [PMID:  22847272 ]
Science. 2012 Jul 20;337(6092):301-2   [PMID:  22822136 ]

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