| Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin. | |
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MedLine Citation:
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PMID: 19222803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The tissue microenvironment plays a critical role in cell survival and growth and can contribute to cell transformation and tumor development. Cellular interactions with the stroma and with other cells provide key signals that control cellular arrest or division, survival or death, and entrance or exit from a quiescent state. Together, these decisions are essential for maintenance of tissue homeostasis. Tissue oxygenation is an important component of the microenvironment that can acutely alter the behavior of a cell through the direct regulation of genes involved in cell survival, apoptosis, glucose metabolism, and angiogenesis. Loss of tissue homeostasis due to, for example, oncogene activation leads to the disruption of these signals and eventually can lead to cell transformation and tumor development. Here we review the role of tissue oxygenation, and in particular physiologic skin hypoxia, on cell survival and senescence and how it contributes to melanocyte transformation and melanoma development. |
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Authors:
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Barbara Bedogni; Marianne Broome Powell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2009-02-13 |
Journal Detail:
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Title: Pigment cell & melanoma research Volume: 22 ISSN: 1755-1471 ISO Abbreviation: Pigment Cell Melanoma Res Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-23 Completed Date: 2009-05-26 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: England |
Other Details:
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Languages: eng Pagination: 166-74 Citation Subset: IM |
Affiliation:
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Division of Radiation and Cancer Biology, Stanford University, Stanford, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Hypoxia Cell Survival Humans Melanocytes / cytology* Melanoma / pathology* Oxygen / metabolism Skin / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA027502-220019/CA/NCI NIH HHS; P01 CA027502-26/CA/NCI NIH HHS; P01CA27502/CA/NCI NIH HHS; R01 CA120526-03/CA/NCI NIH HHS; R01 CA120526-04/CA/NCI NIH HHS; R01CA120526/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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