| Hypoxia and lipid signaling. | |
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MedLine Citation:
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PMID: 17081102 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and respond to hypoxia by upregulating the expression of specific genes, which allows an adaptation to hypoxia-induced stress conditions. The modulation of cell signaling by hypoxia is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing environment. Cell signaling and adaptation processes are often accompanied by rapid and/or chronic remodeling of membrane lipids by activated lipases. This review highlights the bi-directional relation between hypoxia and lipid signaling mechanisms. |
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Authors:
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Andrea Huwiler; Josef Pfeilschifter |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biological chemistry Volume: 387 ISSN: 1431-6730 ISO Abbreviation: Biol. Chem. Publication Date: 2006 Oct-Nov |
Date Detail:
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Created Date: 2006-11-03 Completed Date: 2006-12-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9700112 Medline TA: Biol Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 1321-8 Citation Subset: IM |
Affiliation:
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Pharmazentrum Frankfurt, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Hypoxia Diglycerides / metabolism Humans Lipid Metabolism* Oxygen / metabolism, pharmacology Signal Transduction* |
| Chemical | |
Reg. No./Substance:
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0/Diglycerides; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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