Document Detail

Hypoxia-ischaemia model in the 7-day-old rat: possibilities and shortcomings.
MedLine Citation:
PMID:  9298801     Owner:  NLM     Status:  MEDLINE    
The Levene model in 7-day-old rats is the most often used model of hypoxia-ischaemia (HI) in immature animals. The rat central nervous system is immature at birth and corresponds neurodevelopmentally to the term human infant during the second postnatal week. The Levene model of HI differs from clinical asphyxia with respect to the unilateral distribution of brain injury and lack of multi-organ dysfunction. Furthermore, it does not allow cardiovascular monitoring or repeated blood sampling. On the other hand, the progressive nature of HI bears many similarities to birth asphyxia with regard to blood flow changes and cellular metabolic derangements. The model is well characterized, easy to carry out and the low cost allows inclusion of a sufficient number of animals for dose-response evaluation of neuroprotective agents. In addition, it provides the unique opportunity of long-term evaluation of neuropathological and functional outcome.
H Hagberg; E Bona; E Gilland; M Puka-Sundvall
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992). Supplement     Volume:  422     ISSN:  0803-5326     ISO Abbreviation:  Acta Paediatr Suppl     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-10-15     Completed Date:  1997-10-15     Revised Date:  2008-05-12    
Medline Journal Info:
Nlm Unique ID:  9315043     Medline TA:  Acta Paediatr Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Animals, Newborn
Anoxia / metabolism,  physiopathology*
Asphyxia Neonatorum
Brain Ischemia / metabolism,  physiopathology*
Disease Models, Animal*
Infant, Newborn
Species Specificity

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