| Hypoxia-inducible factors, stem cells, and cancer. | |
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MedLine Citation:
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PMID: 17482542 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regions of severe oxygen deprivation (hypoxia) arise in tumors due to rapid cell division and aberrant blood vessel formation. The hypoxia-inducible factors (HIFs) mediate transcriptional responses to localized hypoxia in normal tissues and in cancers and can promote tumor progression by altering cellular metabolism and stimulating angiogenesis. Recently, HIFs have been shown to activate specific signaling pathways such as Notch and the expression of transcription factors such as Oct4 that control stem cell self renewal and multipotency. As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression. |
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Authors:
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Brian Keith; M Celeste Simon |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Cell Volume: 129 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-07 Completed Date: 2007-06-20 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 465-72 Citation Subset: IM |
Affiliation:
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Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. bkeith@mail.med.upenn.edu <bkeith@mail.med.upenn.edu> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / metabolism Basic Helix-Loop-Helix Transcription Factors / metabolism* Cell Hypoxia Disease Progression Humans Neoplasms / metabolism*, pathology Neoplastic Stem Cells / metabolism* Signal Transduction Stem Cells / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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HL66130/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Basic Helix-Loop-Helix Transcription Factors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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