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Hypoxia-inducible factors as key regulators of tumor inflammation.
MedLine Citation:
PMID:  23055435     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Low levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological disorders like cancer. The main family of transcription factors responsible for cell survival and adaptation under strenuous conditions of hypoxia are the 'Hypoxia-Inducible Factors' (HIFs). Together with Prolyl hydroxylases (PHDs), HIFs regulates tumor angiogenesis, proliferation, invasion, metastasis, in addition to resistance to radiation and chemotherapy. Additionally, the entire HIF transcription cascade is involved in the 'seventh' hallmark of cancer; inflammation. Studies have shown that hypoxia can influence tumor associated immune cells towards assisting in tumor proliferation, differentiation, vessel growth, distant metastasis and suppression of theimmune response via cytokine expression alterations. These changes are not necessarily analogous to HIF's role in non-cancer immune responses, where hypoxia often encourages a strong inflammatory response. © 2012 Wiley Periodicals, Inc.
Authors:
Soulafa Mamlouk; Ben Wielockx
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 UICC.
Affiliation:
Emmy Noether Research Group and Institute of Pathology, University of Technology, Dresden, Germany.
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