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Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image.
MedLine Citation:
PMID:  20596750     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Hypoxia-inducible factor (HIF)-1α and HIF-2α expression were investigated immunohistochemically as determinants of prognosis in 42 cases of astrocytic tumors associated with necrosis grade on magnetic resonance (MR) imaging. Expression of HIF-1α was determined immunohistologically. The degree of necrosis on MR images was divided into four grades. Kaplan-Meier analysis revealed a significant effect of necrosis grade on MR images on cumulative overall survival. Median survival times were 26, 14, and 13 months for patients with necrosis grades 1, 2, and 3, respectively (not defined for grade 0). Kaplan-Meier analysis revealed a significant effect of HIF-1α expression on cumulative overall survival. Median survival time of patients with HIF-1α expression was 17 months, whereas it was 80 months for patients without HIF-1α expression. However, overexpression of HIF-2α did not correlate with malignant features, for example angiogenesis or necrosis, and had no impact on overall survival of patients with glial tumors. In conclusion, HIF-1α, but not HIF-2α, is a useful prognostic factor in astrocytic tumor associated with necrosis on MR images.
Authors:
Ryota Mashiko; Shingo Takano; Eiichi Ishikawa; Tetsuya Yamamoto; Kei Nakai; Akira Matsumura
Publication Detail:
Type:  Journal Article     Date:  2010-07-02
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  102     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki.
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