| Hypoxia-inducible factor-1 inhibitory benzofurans and chalcone-derived diels-alder adducts from Morus species. | |
| | |
MedLine Citation:
|
PMID: 19072214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen concentrations and vital to many aspects of cancer biology. Bioassay-guided fractionation of the chloroform-soluble extracts of Morus species using a hypoxia response element (HRE)-dependent reporter assay led to identification of six benzofurans (1-6) and two chalcone-derived Diels-Alder adducts (7, 8) from Mori Cortex Radicis and three prenylated benzofurans (9-11) and four chalcone-derived Diels-Alder adducts (12-15) from Morus bombycis. The structure of the new 2-arylbenzofuran-type compound, moracin Q (3), was elucidated by spectroscopic methods, and the absolute configuration of 2 was determined for the first time. The selected compounds (1-3, 5, 7, 9, 10, and 12) from the cell-based reporter assay were found to inhibit hypoxia-induced HIF-1alpha accumulation in a dose-dependent manner in human hepatocelluar carcinoma cell-line Hep3B cells. Furthermore, these compounds were also active against hypoxia-induced vascular endothelial growth factor (VEGF) secretion in Hep3B cells. |
| | |
Authors:
|
Nguyen Tien Dat; Xuejun Jin; Kyeong Lee; Young-Soo Hong; Young Ho Kim; Jung Joon Lee |
Related Documents
:
|
19298354 - Photodynamic inactivation of candida albicans by bam-sipc. 15840654 - Manipulation of redox signaling in mammalian cells enabled by controlled photogeneratio... 3528114 - A new photometric method for oxygen consumption measurements in cell suspensions. 9408564 - The influence of hyperbaric oxygenation on leukocyte viability and surface protein expr... 15279834 - Genetic damage in exfoliated cells from oral mucosa of individuals exposed to x-rays du... 21092834 - Impact of prolonged fraction delivery times simulating imrt on cultured nasopharyngeal ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Jan |
Date Detail:
|
Created Date: 2009-01-23 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
|
Languages: eng Pagination: 39-43 Citation Subset: IM |
Affiliation:
|
Center for Molecular Cancer Research, Korean Research Institute of Biosciences and Biotechnology, Daejeon, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents, Phytogenic
/
chemistry,
isolation & purification*,
pharmacology* Benzofurans / chemistry, isolation & purification*, pharmacology* Chalcone / metabolism Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors* Molecular Structure Morus / chemistry* Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal / chemistry* Vascular Endothelial Growth Factor A / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/Benzofurans; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Vascular Endothelial Growth Factor A; 94-41-7/Chalcone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spectroscopic identification of the lithium ion transporting species in LiTFSI-doped ionic liquids.
Next Document: Aqueous V(V)-peroxo-amino acid chemistry. Synthesis, structural and spectroscopic characterization o...