Document Detail

Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells mediated cardiac repair.
MedLine Citation:
PMID:  22873764     Owner:  NLM     Status:  Publisher    
Mesenchymal stem cells (MSC) are effective in treating myocardial infarction and previous reports demonstrated that hypoxia improves MSC self-renewal and therapeutics. Considering that HIF-1α is a master regulator of the adaptative response to hypoxia, we hypothesized that HIF-1α overexpression in MSC could mimic some of the mechanisms triggered by hypoxia and increase their therapeutic potential without hypoxia stimulation. Transduction of MSC with HIF-1α lentivirus vectors (MSC-HIF) resulted in increased cell adhesion and migration, and activation of target genes coding for paracrine factors. When MSC-HIF were injected intramyocardially in infarcted nude rats, significant improvement was found after treatment of infarcted rats with MSC-HIF in terms of cardiac function, angiogenesis, cardiomyocyte proliferation, and reduction of fibrotic tissue with no induction of cardiac hypertrophy. This finding provides evidences for a crucial role of HIF-1α on MSC biology and suggests the stabilization of HIF-1α as a novel strategy for cellular therapies.
Inmaculada Cerrada; Amparo Ruiz-Saurí; Rubén Carrero; César Trigueros; Akaitz Dorronsoro; José-María Sánchez-Puelles; Antonio Diez-Juan; Jose Anastasio Montero; Pilar Sepulveda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  Stem cells and development     Volume:  -     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Fundación Hospital La Fe, Regenerative Medicine and Heart Transplantation Unit, Valencia, Spain;
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