| Hypoxia-inducible factor 1 alpha contributes to cardiac healing in mesenchymal stem cells mediated cardiac repair. | |
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MedLine Citation:
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PMID: 22873764 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Mesenchymal stem cells (MSC) are effective in treating myocardial infarction and previous reports demonstrated that hypoxia improves MSC self-renewal and therapeutics. Considering that HIF-1α is a master regulator of the adaptative response to hypoxia, we hypothesized that HIF-1α overexpression in MSC could mimic some of the mechanisms triggered by hypoxia and increase their therapeutic potential without hypoxia stimulation. Transduction of MSC with HIF-1α lentivirus vectors (MSC-HIF) resulted in increased cell adhesion and migration, and activation of target genes coding for paracrine factors. When MSC-HIF were injected intramyocardially in infarcted nude rats, significant improvement was found after treatment of infarcted rats with MSC-HIF in terms of cardiac function, angiogenesis, cardiomyocyte proliferation, and reduction of fibrotic tissue with no induction of cardiac hypertrophy. This finding provides evidences for a crucial role of HIF-1α on MSC biology and suggests the stabilization of HIF-1α as a novel strategy for cellular therapies. |
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Authors:
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Inmaculada Cerrada; Amparo Ruiz-Saurí; Rubén Carrero; César Trigueros; Akaitz Dorronsoro; José-María Sánchez-Puelles; Antonio Diez-Juan; Jose Anastasio Montero; Pilar Sepulveda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-8 |
Journal Detail:
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Title: Stem cells and development Volume: - ISSN: 1557-8534 ISO Abbreviation: Stem Cells Dev. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197107 Medline TA: Stem Cells Dev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Fundación Hospital La Fe, Regenerative Medicine and Heart Transplantation Unit, Valencia, Spain; inmaculadacerrada@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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