| Hypoxia-induced vasodilation and effects of regional phentolamine in awake patients with sleep apnea. | |
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MedLine Citation:
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PMID: 20223993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obstructive sleep apnea (OSA) is associated with increased sympathetic nerve activity, endothelial dysfunction, and premature cardiovascular disease. To determine whether hypoxia is associated with impaired skeletal muscle vasodilation, we compared femoral artery blood flow (ultrasound) and muscle sympathetic nerve activity (peroneal microneurography) during exposure to acute systemic hypoxia (fraction of inspired oxygen 0.1) in awake patients with OSA (n=10) and controls (n=8). To assess the role of elevated sympathetic nerve activity, in a separate group of patients with OSA (n=10) and controls (n=10) we measured brachial artery blood flow during hypoxia before and after regional alpha-adrenergic block with phentolamine. Despite elevated sympathetic activity, in OSA the vascular responses to hypoxia in the leg did not differ significantly from those in controls [P=not significant (NS)]. Following regional phentolamine, in both groups the hypoxia-induced increase in brachial blood flow was markedly enhanced (OSA pre vs. post, 84+/-13 vs. 201+/-34 ml/min, P<0.002; controls pre vs. post 62+/-8 vs. 140+/-26 ml/min, P<0.01). At end hypoxia after phentolamine, the increase of brachial blood flow above baseline was similar (OSA vs. controls +61+/-16 vs. +48+/-6%; P=NS). We conclude that despite high sympathetic vasoconstrictor tone and prominent sympathetic responses to acute hypoxia, hypoxia-induced limb vasodilation is preserved in OSA. |
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Authors:
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Raman Moradkhan; Brett Spitnale; Patrick McQuillan; Cynthia Hogeman; Kristen S Gray; Urs A Leuenberger |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-11 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 108 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-08-12 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1234-40 Citation Subset: IM |
Affiliation:
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Pennsylvania State Heart and Vascular Institute, Department of Anesthesia, H047, Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, PA 17033, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists* Adult Anoxia / physiopathology*, ultrasonography Autonomic Nerve Block / methods* Brachial Artery / physiopathology*, ultrasonography Case-Control Studies Female Femoral Artery / physiopathology*, ultrasonography Humans Male Middle Aged Muscle, Skeletal / blood supply*, innervation Peroneal Nerve / physiopathology Phentolamine* Regional Blood Flow Skin / blood supply Sleep Apnea, Obstructive / physiopathology*, ultrasonography Sympathetic Nervous System / physiopathology Ultrasonography, Doppler Vasoconstriction Vasodilation* Wakefulness* |
| Grant Support | |
ID/Acronym/Agency:
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C06-RR-016499/RR/NCRR NIH HHS; M01-RR-010732/RR/NCRR NIH HHS; P01-HL-077670/HL/NHLBI NIH HHS; R01-HL-068699/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 50-60-2/Phentolamine |
| Comments/Corrections | |
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