| Hypoxia-induced sickness behaviour. | |
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MedLine Citation:
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PMID: 17242471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sickness behaviour (SB) consists of the set of adaptive responses of the host to severe infections and inflammation. It includes, among others, the thermoregulatory responses such as regulated increase (fever) and/or decrease (anapyrexia) of body temperature (T(b)), decrease of motor activity (lethargy), and loss of appetite (hypophagia) resulting in a transient loss of body weight. It is thought that SB is partially induced by the immune-derived mediators such as cytokines and prostaglandins acting on the central nervous system. It has repeatedly been shown, on the other hand, that severe infections (pneumonia, tissue septicemia) can impair processes of the gases exchange both in the lungs and in distal tissues including brain, which may lead to hypoxia of the affected organs. Therefore, we have tested the hypothesis that hypoxia may also provoke SB. The study was conducted on freely moving biotelemetered mice kept at 28 degrees C ambient and 12/12 h light/dark cycle. We demonstrate that mice exposed for 7 days to hypoxia (11%O(2)) displayed all symptoms of SB. Interleukin-6 deficient mice (IL-6 KO) revealed reduced SB symptoms under hypoxic conditions. Recovery of the hypoxia-exposed mice to a normal rhythm in T(b), motor activity and feeding was unaffected by mepacrine, a phospholipase A(2) blocker. The recovery, however, was significantly impaired by indomethacin, a cyclooxygenase inhibitor. Exposure to hypoxemia resulted in significant elevation of plasma IL-6 in both untreated and treated with lipopolysaccharide (LPS) mice. It inhibited, however, a generation of blood prostaglandins (PGE(2)) in mice. Based on these data we conclude that IL-6 and accumulation of free arachidonic acid in biomembranes contribute to hypoxemia- induced SB. |
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Authors:
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W Kozak; S Wrotek; K Walentynowicz |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 57 Suppl 8 ISSN: 1899-1505 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2007-01-23 Completed Date: 2007-12-06 Revised Date: 2008-05-19 |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 35-50 Citation Subset: IM |
Affiliation:
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Department of Immunology, Institute of General and Molecular Biology, Nicolaus Copernicus University, Toruń, Poland. wkozak@biol.uni.torun.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / blood, enzymology, physiopathology* Behavior, Animal / physiology* Body Temperature / physiology Body Weight / physiology Dinoprostone / blood, physiology* Eating / physiology Fever / blood, enzymology, physiopathology Indomethacin / pharmacology Interleukin-6 / blood, deficiency, physiology* Lipopolysaccharides / pharmacology Male Mice Mice, Inbred C57BL Mice, Knockout Motor Activity / physiology Phospholipases A2 / metabolism Prostaglandin-Endoperoxide Synthases / metabolism Sick Role* Specific Pathogen-Free Organisms |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Lipopolysaccharides; 363-24-6/Dinoprostone; 53-86-1/Indomethacin; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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