Document Detail


Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells.
MedLine Citation:
PMID:  21669489     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypoxia frequently occurs in solid tumors and is known to contribute to chemotherapy resistance. However, the mechanisms leading to chemotherapy resistance are not entirely known. We investigated hypoxia-induced resistance to cisplatin in NSCLC cell lines. We show that chronic moderate hypoxia induced resistance to cisplatin in NSCLC cells without involvement of selection pressure. Our data suggest that stabilization of the hypoxia-inducible factor 1 alpha and down-regulation of the pro-apoptotic protein BAX play a role in this process. Furthermore, we provide evidence that hypoxia-induced resistance to cisplatin is not due to the reduced growth rate of cancer cells under hypoxic conditions.
Authors:
Christoph Wohlkoenig; Katharina Leithner; Alexander Deutsch; Andelko Hrzenjak; Andrea Olschewski; Horst Olschewski
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-11
Journal Detail:
Title:  Cancer letters     Volume:  -     ISSN:  1872-7980     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria; Lung Cell Laboratory, Medical University of Graz, Graz, Austria.
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