Document Detail

Hypoxia increases glucose transport at blood-brain barrier in rats.
MedLine Citation:
PMID:  8002545     Owner:  NLM     Status:  MEDLINE    
Prolonged hypoxia causes several adaptive changes in systemic physiology and tissue metabolism. We studied the effects of hypobaric hypoxia on glucose transport at the blood-brain barrier (BBB) in the rat. We found that hypoxia increased the density of brain microvessels seen on immunocytochemical stains using an antibody to the glucose transporting protein GLUT. In addition, we found that hypoxia increased the density of GLUT in isolated cerebral microvessels as determined by specific cytochalasin B binding. The higher GLUT density in isolated cerebral microvessels was evident after 1 wk of hypoxia and was associated with decreased activity of gamma-glutamyltranspeptidase. Consistent with these findings, we also demonstrated that 3 wk of hypobaric hypoxia caused increased unidirectional transport of glucose at the BBB in several brain regions in vivo, as determined by the doubly labeled single-pass indicator-fractionation atrial bolus injection method in anesthetized rats. We conclude that chronic hypobaric hypoxia is associated with increased glucose transport at the BBB.
S I Harik; R A Behmand; J C LaManna
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-20     Completed Date:  1995-01-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  896-901     Citation Subset:  IM    
Department of Neurology, University Hospitals of Cleveland, Ohio.
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MeSH Terms
Anoxia / metabolism*
Blood Glucose / metabolism
Blood-Brain Barrier*
Body Weight / physiology
Brain Chemistry / physiology
Glucose / metabolism*
Glucose Transporter Type 1
Monosaccharide Transport Proteins / metabolism
Rats, Wistar
gamma-Glutamyltransferase / metabolism
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Glucose Transporter Type 1; 0/Monosaccharide Transport Proteins; 50-99-7/Glucose; EC

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