Document Detail


Hypoxia increases glucose transport at blood-brain barrier in rats.
MedLine Citation:
PMID:  8002545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolonged hypoxia causes several adaptive changes in systemic physiology and tissue metabolism. We studied the effects of hypobaric hypoxia on glucose transport at the blood-brain barrier (BBB) in the rat. We found that hypoxia increased the density of brain microvessels seen on immunocytochemical stains using an antibody to the glucose transporting protein GLUT. In addition, we found that hypoxia increased the density of GLUT in isolated cerebral microvessels as determined by specific cytochalasin B binding. The higher GLUT density in isolated cerebral microvessels was evident after 1 wk of hypoxia and was associated with decreased activity of gamma-glutamyltranspeptidase. Consistent with these findings, we also demonstrated that 3 wk of hypobaric hypoxia caused increased unidirectional transport of glucose at the BBB in several brain regions in vivo, as determined by the doubly labeled single-pass indicator-fractionation atrial bolus injection method in anesthetized rats. We conclude that chronic hypobaric hypoxia is associated with increased glucose transport at the BBB.
Authors:
S I Harik; R A Behmand; J C LaManna
Related Documents :
3749605 - Inhibition of isoproterenol positive atrial chronotropic effect by methylmethacrylate p...
8789295 - Vasodilator action of the s-nitrosothiol, snap, in rat isolated perfused lung.
10447655 - Polyamine system in developing rat eye and an animal model of retinopathy of prematurity.
16636055 - Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismut...
7535795 - Direct gene delivery of human tissue kallikrein reduces blood pressure in spontaneously...
3420945 - Effects of 1,2-dibromoethane on isolated hepatocytes: functional alterations and induct...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-20     Completed Date:  1995-01-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  896-901     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospitals of Cleveland, Ohio.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anoxia / metabolism*
Blood Glucose / metabolism
Blood-Brain Barrier*
Body Weight / physiology
Brain Chemistry / physiology
Glucose / metabolism*
Glucose Transporter Type 1
Hematocrit
Kinetics
Male
Monosaccharide Transport Proteins / metabolism
Rats
Rats, Wistar
gamma-Glutamyltransferase / metabolism
Grant Support
ID/Acronym/Agency:
HL-35617/HL/NHLBI NIH HHS; HL-42215/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Glucose Transporter Type 1; 0/Monosaccharide Transport Proteins; 50-99-7/Glucose; EC 2.3.2.2/gamma-Glutamyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung inju...
Next Document:  Hyperbaric oxygenation increases arousal and breathing movements in fetal lambs.