Document Detail


Hypoxia and acidity increase the cytotoxicity of mitomycin C and carboquone to human tumor cells in vitro.
MedLine Citation:
PMID:  1746896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To clarify the influence of hypoxic and acidic environments on the cytotoxicity of mitomycin C (MMC) and carboquone (CQ), the cytotoxicity was assessed based on decreases in intracellular ATP levels of HeLa cells exposed to the drugs at various acidic pH (pH 5.8-6.8) and low oxygen tension (5% and 0% O2) in vitro. Hypoxia and acidity individually increased the cytotoxicity of MMC, although hypoxia no longer increased it under acidic conditions. On the other hand, the cytotoxicity of CQ was enhanced in the presence of hypoxic and acidic conditions, and even more so with their combination. We conclude that acidity is a determining factor and excels hypoxia in influencing the cytotoxicity of MMC and that these two factors act synergistically on CQ.
Authors:
S Kohnoe; Y Emi; I Takahashi; M Yoshida; Y Maehara; K Sugimachi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  11     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1992-01-10     Completed Date:  1992-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1401-4     Citation Subset:  IM    
Affiliation:
Cancer Center, Kyushu University Hospital, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism*
Carbazilquinone / pharmacology*
Cell Hypoxia*
Cell Survival / drug effects*
Hela Cells
Humans
Hydrogen-Ion Concentration
Kinetics
Mitomycin / pharmacology*
Chemical
Reg. No./Substance:
24279-91-2/Carbazilquinone; 50-07-7/Mitomycin; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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