Document Detail

Hypoxia and acidity increase the cytotoxicity of mitomycin C and carboquone to human tumor cells in vitro.
MedLine Citation:
PMID:  1746896     Owner:  NLM     Status:  MEDLINE    
To clarify the influence of hypoxic and acidic environments on the cytotoxicity of mitomycin C (MMC) and carboquone (CQ), the cytotoxicity was assessed based on decreases in intracellular ATP levels of HeLa cells exposed to the drugs at various acidic pH (pH 5.8-6.8) and low oxygen tension (5% and 0% O2) in vitro. Hypoxia and acidity individually increased the cytotoxicity of MMC, although hypoxia no longer increased it under acidic conditions. On the other hand, the cytotoxicity of CQ was enhanced in the presence of hypoxic and acidic conditions, and even more so with their combination. We conclude that acidity is a determining factor and excels hypoxia in influencing the cytotoxicity of MMC and that these two factors act synergistically on CQ.
S Kohnoe; Y Emi; I Takahashi; M Yoshida; Y Maehara; K Sugimachi
Related Documents :
365756 - Hyporeactivity factor produced after induction of immune interferon in mice sensitized ...
16154506 - Effect of hydraulic retention time on anaerobic hydrogenesis in cstr.
20596766 - Acidic and basic properties and buffer capacity of airborne particulate matter in an ur...
20083776 - In vitro effects of acid and pepsin on mouse middle ear epithelial cell viability and m...
8274526 - Synthesis of 3-(triethylstannyl)propanoic acid: an organotin mass label for dna.
811656 - Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  11     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1992-01-10     Completed Date:  1992-01-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1401-4     Citation Subset:  IM    
Cancer Center, Kyushu University Hospital, Fukuoka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism*
Carbazilquinone / pharmacology*
Cell Hypoxia*
Cell Survival / drug effects*
Hela Cells
Hydrogen-Ion Concentration
Mitomycin / pharmacology*
Reg. No./Substance:
24279-91-2/Carbazilquinone; 50-07-7/Mitomycin; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical evaluation of the new tumor marker TAG-72.
Next Document:  The initial steps of tumor progression in melanocytic lineage: a histochemical approach.