| Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. | |
| | |
MedLine Citation:
|
PMID: 21517900 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
To cite this article: Huerta-Yepez S, Baay-Guzman GJ, Bebenek IG, Hernandez-Pando R, Vega MI, Chi L, Riedl M, Diaz-Sanchez D, Kleerup E, Tashkin DP, Gonzalez FJ, Bonavida B, Zeidler M, Hankinson O. Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02594.x. ABSTRACT: Background: New therapies are necessary to address inadequate asthma control in many patients. This study sets out to investigate whether hypoxia-inducible factor (HIF) is essential for development of allergic airway inflammation (AAI) and therefore a potential novel target for asthma treatment. Methods: Mice conditionally knocked out for HIF-1β were examined for their ability to mount an allergic inflammatory response in the lung after intratracheal exposure to ovalbumin. The effects of treating wild-type mice with either ethyl-3,4-dihydroxybenzoate (EDHB) or 2-methoxyestradiol (2ME), which upregulate and downregulate HIF, respectively, were determined. HIF-1α levels were also measured in endobronchial biopsies and bronchial fluid of patients with asthma and nasal fluid of patients with rhinitis after challenge. Results: Deletion of HIF-1β resulted in diminished AAI and diminished production of ovalbumin-specific IgE and IgG(1) . EDHB enhanced the inflammatory response, which was muted upon simultaneous inhibition of vascular endothelial growth factor (VEGF). EDHB and 2ME antagonized each other with regard to their effects on airway inflammation and mucus production. The levels of HIF-1α and VEGF increased in lung tissue and bronchial fluid of patients with asthma and in the nasal fluid of patients with rhinitis after challenge. Conclusions: Our results support the notion that HIF is directly involved in the development of AAI. Most importantly, we demonstrate for the first time that HIF-1α is increased after challenge in patients with asthma and rhinitis. Therefore, we propose that HIF may be a potential therapeutic target for asthma and possibly for other inflammatory diseases. |
| | |
Authors:
|
S Huerta-Yepez; G J Baay-Guzman; I G Bebenek; R Hernandez-Pando; M I Vega; L Chi; M Riedl; D Diaz-Sanchez; E Kleerup; D P Tashkin; F J Gonzalez; B Bonavida; M Zeidler; O Hankinson |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-26 |
Journal Detail:
|
Title: Allergy Volume: - ISSN: 1398-9995 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804028 Medline TA: Allergy Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Unidad de Investigacion En enfermedades Oncologicas, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Experimental Pathology Section, Department of Pathology, National Institute of Medical Science and Nutrition, Salvador Zubiran Unidad de Investigacion Medica en Enfermedades Oncologica, Hospital de Oncologia CMN siglo XXI, IMSS, Mexico City, Mexico Department of Clinical Immunology and Allergy, David Geffen School of Medicine, UCLA, Los Angeles, CA Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Chapel Hill, NC Pulmonary and Critical Care Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA Laboratory of Metabolism, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD Department of Microbiology Immunology and Molecular Genetics, UCLA, Los Angeles, CA WLA-VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Los Angeles, CA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: This ought to be good: Brain activity accompanying positive and negative expectations and outcomes.
Next Document: When persons disagree: An ERP study of Unagreement in Spanish.