| Hypoxia-Inducible Factor-1α Downregulation by Small Interfering RNA Inhibits Proliferation, Induces Apoptosis, and Enhances Radiosensitivity in Chemical Hypoxic Human Hepatoma SMMC-7721 Cells. | |
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MedLine Citation:
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PMID: 21950556 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Radiation plays an important role in the treatment of hepatoma. In order to improve its therapeutic ratio, there has been much interest in augmenting the effect of radiation on tumors by combining it with molecularly targeted therapeutics. Hypoxia-inducible factor-1 (HIF-1) is an excellent potential candidate for targeted molecular therapy to improve radiation outcome. In this study, HIF-1α-targeted small interfering RNA (siRNA) expression vector was constructed and transfected into human hepatoma SMMC-7721 cells, which followed by culture in CoCl(2)-induced hypoxia. HIF-1α downregulation by siRNA inhibited proliferation, induced apoptosis, and enhanced radiosensitivity in chemical hypoxic SMMC-7721 cells in vitro. These findings suggest that specific inhibition of HIF-1α expression in combination with radiotherapy would be expected to exert a strong antitumor effect on human hepatoma. |
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Authors:
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Wei Yang; Ting Sun; Jianping Cao; Saijun Fan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-27 |
Journal Detail:
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Title: Cancer biotherapy & radiopharmaceuticals Volume: - ISSN: 1557-8852 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605408 Medline TA: Cancer Biother Radiopharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Department of Radiobiology, School of Radiological Medicine and Public Health, Soochow University , Suzhou, China . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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