Document Detail

Hypoxia induced changes in lung fluid balance in humans is associated with beta-2 adrenergic receptor density on lymphocytes.
MedLine Citation:
PMID:  22772314     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies have demonstrated an important role for beta-2 adrenergic receptors (β(2)AR) in lung fluid clearance. The purpose of this investigation was to examine the relationship between β(2)AR density on lymphocytes and indices of lung water in healthy humans exposed to ≈ 17 h of hypoxia (FIO2 = 12.5% in a hypoxia tent).
METHODS: Thirteen adults (mean ± SEM; age=31 ± 3 years, BMI=24 ± 1 kg/m(2), VO2 Peak = 40 ± 2 ml/kg/min ) participated. Pulmonary function, CT derived lung tissue volume (V(tis)-tissue, blood and water), lung diffusing capacity for carbon monoxide (D(CO)) and nitric oxide (D(NO)), alveolar-capillary conductance (D(M)), pulmonary capillary blood volume (V(c)) and lung water (CT V(tis)-V(c)) were assessed before and after ≈ 17 h normobaric hypoxia (FIO2 = 12.5%). β(2)AR density on lymphocytes was measured via radioligand binding. Arterial oxygen saturation (SaO2), cardiac output (Q), right ventricular systolic pressure (RVSP) and blood pressure (BP) were also assessed.
RESULTS: After 17 h hypoxia, SaO2 decreased from 97 ± 1 (normoxia) to 82 ± 4% and RVSP increased from 14 ± 3 (normoxia) to 29 ± 2 mmHg (p<0.05) with little change in Q or BP. V(c) and D(M) both increased with hypoxia with a small increase in D(M)/V(c) ratio (p>0.05). CT V(tis) decreased and lung water was estimated to decline 7 ± 13%, respectively. β(2)AR density averaged 1497 ± 187 receptors/lymphocyte and increased 21 ± 34% with hypoxia (range -31 to +86%). The post-hypoxia increase in β(2)AR density was significantly related to the reduction in lung water (r=-0.64, p<0.05), with the subjects with the greatest increase in density demonstrating the largest decline in lung water.
CONCLUSIONS: Lung water decreases with 17 h normobaric hypoxia are associated with changes in beta adrenergic receptor density on lymphocytes in healthy adults.
Micah W Johnson; Bryan J Taylor; Minelle L Hulsebus; Bruce D Johnson; Eric M Snyder
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-03
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  183     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-31     Completed Date:  2013-01-04     Revised Date:  2013-08-19    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
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MeSH Terms
Blood Pressure / physiology
Carbon Monoxide / blood,  physiology
Cardiac Output / physiology
Lung / physiopathology*
Lymphocytes / physiology*
Nitric Oxide / blood,  physiology
Oxygen / blood,  physiology*
Oxygen Consumption / physiology
Receptors, Adrenergic, beta-2 / analysis,  metabolism*
Respiratory Function Tests
Ventricular Function / physiology
Water-Electrolyte Balance / physiology*
Grant Support
Reg. No./Substance:
0/Receptors, Adrenergic, beta-2; 10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide; 7782-44-7/Oxygen

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