Document Detail

Hypoxemia-orthodeoxia related to patent foramen ovale without pulmonary hypertension.
MedLine Citation:
PMID:  18790339     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patent foramen ovale (PFO) is frequent but rarely associated with platypnea-orthodeoxia syndrome and with no pulmonary hypertension. MATERIALS AND METHODS: We performed a retrospective analysis of 12 consecutive patients with hypoxemia and PFO without increased pulmonary arterial pressure. The study was conducted at a single-center university hospital. We analyzed the patients' clinical records, gas exchange, contrast echocardiography studies, and survival. RESULTS: Twelve patients, aged 73.1 +/- 9.5 years, were diagnosed with PFO between 1993 and 2005. All patients experienced dyspnea and/or hypoxemia. Six right hemidiaphragmatic elevations were observed on radiography. The shunt was apparent in three patients using transthoracic echocardiography and in all patients using transesophageal echocardiography. The mean follow-up was 27.6 +/- 32.9 months. The PFO was closed in eight patients, six via percutaneous approach and two via surgery. CONCLUSION: PFO may be patent and responsible for hypoxemia without pulmonary hypertension. This condition is easily recognized with transesophageal echocardiography, leading in most cases to a percutaneous closure resulting in a dramatic correction of hypoxemia.
Anne Claire Toffart; Hélène Bouvaist; Virginie Feral; Dominique Blin; Christophe Pison
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  37     ISSN:  1527-3288     ISO Abbreviation:  Heart Lung     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-09-15     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  AIM; IM    
Pôle Médecine Aiguë et Communautaire, Pneumologie, Centre Hospitalier Universitaire de Grenoble, Université de Grenoble, France.
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MeSH Terms
Aged, 80 and over
Anoxia / diagnosis*,  etiology*,  surgery
Dyspnea / diagnosis,  etiology
Echocardiography, Transesophageal
Follow-Up Studies
Foramen Ovale, Patent / complications*,  diagnosis,  surgery
Hypertension, Pulmonary / etiology
Lung Neoplasms / complications,  surgery
Obesity / complications
Postoperative Complications
Pulmonary Gas Exchange
Rare Diseases
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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