Document Detail

Hypoxemia and acute mountain sickness: which comes first?
MedLine Citation:
PMID:  19115910     Owner:  NLM     Status:  MEDLINE    
Hypoxemia is usually associated with acute mountain sickness (AMS), but most studies have varied in time and magnitude of altitude exposure, exercise, diet, environmental conditions, and severity of pulmonary edema. We wished to determine whether hypoxemia occurred early in subjects who developed subsequent AMS while resting at a simulated altitude of 426 mmHg (approximately 16,000 ft or 4880 m). Exposures of 51 men and women were carried out for 8 to 12 h. AMS was determined by Lake Louise (LL) and AMS-C scores near the end of exposure, with spirometry and gas exchange measured the day before (C) and after 1 (A1), 6 (A6), and last (A12) h at simulated altitude and arterial blood at C, A1, and A12. Responses of 16 subjects having the lowest AMS scores (nonAMS: mean LL=1.0, range=0-2.5) were compared with the 16 having the highest scores (+AMS: mean LL=7.4, range=5-11). Total and alveolar ventilation responses to altitude were not different between groups. +AMS had significantly lower PaO2 (4.6 mmHg) and SaO2 (4.8%) at A1 and 3.3 mmHg and 3.1% at A12. Spirometry changes were similar at A1, but at A6 and A12 reduced vital capacity (VC) and increased breathing frequency suggested interstitial pulmonary edema in +AMS. The early hypoxemia in +AMS appears to be the result of diffusion impairment or venous admixture, perhaps due to a unique autonomic response affecting pulmonary perfusion. Early hypoxemia may be useful to predict AMS susceptibility.
Jack A Loeppky; Milton V Icenogle; Gerald A Charlton; Carole A Conn; Damon Maes; Katrina Riboni; Lee Gates; Marcos F Vidal Melo; Robert C Roach
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  9     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-9     Citation Subset:  IM; S    
Cardiology Section, VA Medical Center, Albuquerque, New Mexico 87108, USA.
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MeSH Terms
Acute Disease
Altitude Sickness / complications*
Anoxia / complications*
Disease Susceptibility
Environmental Exposure
Predictive Value of Tests
Prospective Studies
Pulmonary Gas Exchange / physiology*
Pulmonary Ventilation / physiology*
Respiratory Function Tests
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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