Document Detail

Hypoxanthine in vitreous humor and cerebrospinal fluid--a marker of postmortem interval and prolonged (vital) hypoxia? Remarks also on hypoxanthine in SIDS.
MedLine Citation:
PMID:  8206451     Owner:  NLM     Status:  MEDLINE    
Hypoxanthine (Hx) is a degradation product of adenosine. Increased concentrations were reported in cases of hypoxia as well as with prolonged postmortem interval (PMI). Hx is recommended as an indicator of prolonged (cerebral) hypoxia, for example in vitamins of sudden infant death as well as a new biochemical method for estimation of postmortem time. The correlation of vitreous Hx values with the time since death was reported to be even higher than the vitreous potassium (K+) values. The authors' investigations on 92 bodies with known time since death gave a completely opposite result: a much higher correlation between vitreous K+ and time since death than vitreous Hx. The possible discrepancies between these different results will be discussed (disturbing of intra-ocular fluid dynamics by repeated sample-taking in the study of Rognum et al. The results published so far on vitreous Hx values in sudden infant death syndrome (SIDS) cases as an indicator for a prolonged cerebral hypoxia are also not convincing. When vitreous concentrations of newborn infants or infants of age < 6 months are compared to those of older infants or adults the vitreous diameter must be taken into consideration (diffusion gradient; Fick's law of diffusion). The discrepant results on vitreous Hx as a measure of vital hypoxia and PMI will be discussed. The authors' results on Hx determinations on cerebrospinal fluid in comparison to cerebrospinal spinal (CSF) potassium will also be briefly addressed.
B Madea; H Käferstein; N Hermann; G Sticht
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Forensic science international     Volume:  65     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-11     Completed Date:  1994-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  19-31     Citation Subset:  IM    
Institut für Rechtsmedizin, Universität zu Köln, Germany.
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MeSH Terms
Aged, 80 and over
Anoxia / metabolism*
Child, Preschool
Hypoxanthines / analysis*
Infant, Newborn
Middle Aged
Postmortem Changes*
Potassium / analysis*
Sudden Infant Death / cerebrospinal fluid*
Vitreous Body / chemistry*
Reg. No./Substance:
0/Hypoxanthines; 68-94-0/Hypoxanthine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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