Document Detail

Hypovitaminosis D and osteopenia/osteoporosis in a haemophilia population: a study in HCV/HIV or HCV infected patients.
MedLine Citation:
PMID:  22776099     Owner:  NLM     Status:  MEDLINE    
Recent reports show a correlation between haemophilia and osteoporosis. HIV, HCV and their treatments are independently associated with an increased risk of osteoporosis. Vitamin D plays a pivotal role in bone mineralization. The aim of our study was to compare Vitamin D levels, bone metabolism markers and bone mineral density (BMD) in patients with haemophilia with or without co-infections. Seventy-eight adult patients with severe or moderate haemophilia A or B were subdivided into three groups of 26 patients each (HIV-HCV co-infected, HCV mono-infected and uninfected). The BMD was measured by dual energy X-ray absorptiometry (DXA) at both the femoral area (F) and lumbar spine (L). This was correlated to laboratory values and haemophilic arthropathy was assessed using validated clinical and radiological scores. The DXA showed a homogeneous F-BMD reduction in all the three groups, whereas L-BMD was significantly lower in co-infected patients (P < 0.05). The clinical score was higher in co-infected (P < 0.002) and mono-infected (P < 0.006). The radiological score was higher in mono-infected than in the other two groups (P < 0.001). Overall 25-hydroxyvitamin D (25-OH Vit D) was reduced (87%). Bone-specific alkaline phosphatase (b-ALP) and telopeptide were increased in co-infected (P < 0.001 and P < 0.01) and mono-infected (P < 0.001 and P < 0.02). The result of the homogeneous F-BMD reduction in all groups could be explained by the pivotal role of arthropathy; the lower L-BMD in co-infected and the increase of b-ALP and telopeptide in co-infected and mono-infected groups suggest faster bone metabolism in case of infections.
S Linari; G Montorzi; D Bartolozzi; M Borderi; D Melchiorre; M Benelli; M Morfini
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Publication Detail:
Type:  Journal Article     Date:  2012-07-09
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  19     ISSN:  1365-2516     ISO Abbreviation:  Haemophilia     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-05-14     Revised Date:  2013-10-10    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Agency for Haemophilia, University Hospital of Firenze, Firenze.
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MeSH Terms
Biological Markers
Bone Density / physiology
Bone Diseases, Metabolic / complications,  etiology*,  metabolism
Bone and Bones / metabolism
HIV Infections / complications*,  metabolism,  physiopathology
Hemophilia A / complications*,  metabolism,  physiopathology
Hemophilia B / complications*,  metabolism,  physiopathology
Hepatitis C / complications*,  metabolism,  physiopathology
Middle Aged
Osteoporosis / complications,  etiology,  metabolism
Vitamin D / analogs & derivatives,  analysis
Vitamin D Deficiency / complications,  etiology*
Young Adult
Reg. No./Substance:
0/Biological Markers; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comment In:
Haemophilia. 2013 Sep;19(5):e308-10   [PMID:  23710553 ]
Haemophilia. 2013 Sep;19(5):e316-8   [PMID:  23781867 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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