Document Detail

Hypovitaminosis D as Predisposing Factor for Atrophic Type A Gastritis: a Case-Control Study and Review of the Literature on the Interaction of Vitamin D with the Immune System.
MedLine Citation:
PMID:  21286859     Owner:  NLM     Status:  Publisher    
1,25-Dihydroxyvitamin D displays immunoregulatory and anti-inflammatory properties, and the cells involved in innate and adaptive immune response express the vitamin D receptor and can both produce and respond to this hormone. This article aims at describing the complex immune regulatory role of vitamin D and depicting whether a correlation exists between atrophic type A gastritis and hypovitaminosis. We studied 62 autoimmune gastritis (AIG) patients and compared them to 54 lymphocytic gastritis patients, 21 Helicobacter pylori gastritis patients and 212 healthy subjects. We also statistically analyzed vitamin D concentration in 36,384 outpatients referred to our clinical laboratories. 25-Hydroxyvitamin D levels, the measurable metabolite used to determine vitamin D status in plasma, were measured by a chemiluminescent method. Average level of 25-OHD in AIG subjects was 9.8 ± 5.6 ng/mL (95% confidence interval (CI) 8.4-11.2), 11.1 ± 8.4 (CI 7.5-14.7) in H. pylori gastritis patients, 22.2 ± 13.5 (CI 18.6-25.8) in nonspecific lymphocytic gastritis patients, 21.3 ± 12.2 (CI 19.7-22.9) in healthy subjects, and 21.8 ± 13.1 (CI 21.7-21.9) in the 36,384 outpatients. Vitamin D levels in AIG patients were significantly lower than in patients with nonspecific gastritis or in the general population, supporting the hypothesis that hypovitaminosis D might be a risk factor for the development of autoimmune diseases. The low vitamin D concentration in H. pylori gastritis patients might act as predisposing factor for a more severe Th1-type aggression to the stomach epithelium.
Antonio Antico; Renato Tozzoli; Davide Giavarina; Elio Tonutti; Nicola Bizzaro
Related Documents :
835559 - The usefulness of stool screening for diagnosing cholelithiasis in acute pancreatitis. ...
19525579 - Effects in the control of edema of the papilla of vater by epinephrine saline irrigatio...
17015559 - The spectrum of valproic acid-associated pancreatitis.
16481969 - Oddi's sphincter dysfunction.
9865559 - Routine biliary sphincterotomy may not be indispensable for endoscopic pancreatic sphin...
20962669 - Clinical profile of calcific and noncalcific chronic pancreatitis in north india.
23098889 - Normal karyotype calla-positive adult pre-b all: dismal outcome with chemotherapy for p...
25062709 - Tear film inflammatory mediators in patients with keratoconus.
9583849 - Biochemical assessment of the nutritional status of cystic fibrosis patients treated wi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-1
Journal Detail:
Title:  Clinical reviews in allergy & immunology     Volume:  -     ISSN:  1559-0267     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504368     Medline TA:  Clin Rev Allergy Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Clinical Pathology, Cittadella General Hospital, Cittadella, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nuclear structure, organization, and oncogenesis.
Next Document:  DW-MRI ADC values can predict treatment response in patients with locally advanced breast cancer und...