| Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly. | |
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MedLine Citation:
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PMID: 20199987 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There have been methodological problems for studying hypovitaminosis D and K in the elderly. First, studies were done either by evaluating food intake or measuring their circulating levels, but rarely by both in Japan. In this paper, vitamin D and K intakes and their circulating levels were simultaneously determined. Second issue is whether hypovitaminosis D and K are independent of general malnutrition, prevalent in the elderly. We tried to statistically discriminate them by principal component analysis (PCA). Fifty institutionalized elderly were evaluated for their circulating 25 hydroxy-vitamin D (25OH-D), intact parathyroid hormone (PTH), phylloquinone (PK), menaquinone-7 (MK-7) levels, and their food intake. Although average vitamin D intake (7.0 microg/day) exceeded the Japanese Adequate Intake (AI) of 5.0 microg/day, average serum 25OH-D concentration was in the hypovitaminosis D range (11.1 ng/mL). Median vitamin K intake was 168 microg/day, approximately 2.5 times as high as AI for vitamin K. Nevertheless, plasma PK and MK-7 concentrations were far lower than those of healthy Japanese elderly over 70 years old. PCA yielded four components; each representing overall nutritional, vitamin K2, vitamin D, and vitamin K1 status, respectively. Since these components are independent of each other, vitamin D- and K-deficiency in these subjects could not be explained by overall malnutrition alone. In summary, institutionalized elderly had a high prevalence of hypovitaminosis D and K, and the simultaneous determination of their circulating level and dietary intake is mandatory in such studies. PCA would yield fruitful results for eliminating the interference by confounders in a cross-sectional study. |
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Authors:
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Akiko Kuwabara; Masako Himeno; Naoko Tsugawa; Maya Kamao; Minori Fujii; Nobuko Kawai; Miyuki Fukuda; Yoko Ogawa; Shoko Kido; Toshio Okano; Kiyoshi Tanaka |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Asia Pacific journal of clinical nutrition Volume: 19 ISSN: 0964-7058 ISO Abbreviation: Asia Pac J Clin Nutr Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-04 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440304 Medline TA: Asia Pac J Clin Nutr Country: Australia |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Department of Food and Nutrition, Kyoto Women's University, 35, Imakumano-kitahiyoshicho, Higashiyama 605-8501 Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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25-Hydroxyvitamin D 2
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blood Aged Aged, 80 and over Biological Markers / blood Body Mass Index Calcifediol / blood Diet Female Humans Institutionalization / statistics & numerical data* Japan / epidemiology Male Malnutrition / blood, epidemiology* Nutritional Status* Parathyroid Hormone / blood Principal Component Analysis Sex Characteristics Vitamin D Deficiency / blood*, epidemiology* Vitamin K 1 / blood Vitamin K 2 / analogs & derivatives, blood Vitamin K Deficiency / blood*, epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Parathyroid Hormone; 11032-49-8/Vitamin K 2; 19356-17-3/Calcifediol; 2124-57-4/vitamin MK 7; 21343-40-8/25-Hydroxyvitamin D 2; 84-80-0/Vitamin K 1 |
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