Document Detail

Hypovitaminosis D and K are highly prevalent and independent of overall malnutrition in the institutionalized elderly.
MedLine Citation:
PMID:  20199987     Owner:  NLM     Status:  MEDLINE    
There have been methodological problems for studying hypovitaminosis D and K in the elderly. First, studies were done either by evaluating food intake or measuring their circulating levels, but rarely by both in Japan. In this paper, vitamin D and K intakes and their circulating levels were simultaneously determined. Second issue is whether hypovitaminosis D and K are independent of general malnutrition, prevalent in the elderly. We tried to statistically discriminate them by principal component analysis (PCA). Fifty institutionalized elderly were evaluated for their circulating 25 hydroxy-vitamin D (25OH-D), intact parathyroid hormone (PTH), phylloquinone (PK), menaquinone-7 (MK-7) levels, and their food intake. Although average vitamin D intake (7.0 microg/day) exceeded the Japanese Adequate Intake (AI) of 5.0 microg/day, average serum 25OH-D concentration was in the hypovitaminosis D range (11.1 ng/mL). Median vitamin K intake was 168 microg/day, approximately 2.5 times as high as AI for vitamin K. Nevertheless, plasma PK and MK-7 concentrations were far lower than those of healthy Japanese elderly over 70 years old. PCA yielded four components; each representing overall nutritional, vitamin K2, vitamin D, and vitamin K1 status, respectively. Since these components are independent of each other, vitamin D- and K-deficiency in these subjects could not be explained by overall malnutrition alone. In summary, institutionalized elderly had a high prevalence of hypovitaminosis D and K, and the simultaneous determination of their circulating level and dietary intake is mandatory in such studies. PCA would yield fruitful results for eliminating the interference by confounders in a cross-sectional study.
Akiko Kuwabara; Masako Himeno; Naoko Tsugawa; Maya Kamao; Minori Fujii; Nobuko Kawai; Miyuki Fukuda; Yoko Ogawa; Shoko Kido; Toshio Okano; Kiyoshi Tanaka
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Asia Pacific journal of clinical nutrition     Volume:  19     ISSN:  0964-7058     ISO Abbreviation:  Asia Pac J Clin Nutr     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440304     Medline TA:  Asia Pac J Clin Nutr     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Department of Food and Nutrition, Kyoto Women's University, 35, Imakumano-kitahiyoshicho, Higashiyama 605-8501 Japan.
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MeSH Terms
25-Hydroxyvitamin D 2 / blood
Aged, 80 and over
Biological Markers / blood
Body Mass Index
Calcifediol / blood
Institutionalization / statistics & numerical data*
Japan / epidemiology
Malnutrition / blood,  epidemiology*
Nutritional Status*
Parathyroid Hormone / blood
Principal Component Analysis
Sex Characteristics
Vitamin D Deficiency / blood*,  epidemiology*
Vitamin K 1 / blood
Vitamin K 2 / analogs & derivatives,  blood
Vitamin K Deficiency / blood*,  epidemiology*
Reg. No./Substance:
0/Biological Markers; 0/Parathyroid Hormone; 11032-49-8/Vitamin K 2; 19356-17-3/Calcifediol; 2124-57-4/vitamin MK 7; 21343-40-8/25-Hydroxyvitamin D 2; 84-80-0/Vitamin K 1

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