Document Detail


Hypouricemic effects of acacetin and 4,5-o-dicaffeoylquinic acid methyl ester on serum uric acid levels in potassium oxonate-pretreated rats.
MedLine Citation:
PMID:  16327155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of acacetin (1) and 4,5-O-dicaffeoylquinic acid methyl ester (2), compounds contained in the flowers of Chrysanthemum sinense SABINE, on the serum uric acid level were investigated using the rats pretreated with the uricase inhibitor potassium oxonate as an animal model for hyperuricemia. When administered per orally at doses of 20 and 50 mg/kg, 1 reduced the serum uric acid level by 49.9 and 63.9%, respectively and 2 reduced the level by 31.2 and 44.4%, respectively. On the other hand, when the same doses were given intraperitoneally, both of compounds also exhibited a dose-dependent and more marked reduction of the serum uric acid level (% reduction at 20 and 50 mg/kg were 63.0 and 95.1% in 1, respectively and 66.9 and 86.5% in 2, respectively). Furthermore, the compounds 1 and 2 inhibited the rat liver xanthine oxidase activity with IC(50) values of 2.22 muM and 5.27 muM, respectively. These results demonstrated the hypouricemic action of 1 and 2, which may be attributable to their xanthine oxidase inhibitory activity.
Authors:
Mai Thanh Thi Nguyen; Suresh Awale; Yasuhiro Tezuka; Liying Shi; Syed Faisal Haider Zaidi; Jun-ya Ueda; Quan Le Tran; Yukihisa Murakami; Kinzo Matsumoto; Shigetoshi Kadota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  28     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-03-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2231-4     Citation Subset:  IM    
Affiliation:
Division of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Allopurinol / pharmacology,  therapeutic use
Animals
Chrysanthemum
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Esters / pharmacology,  therapeutic use*
Flavones / pharmacology,  therapeutic use*
Hyperuricemia / chemically induced,  drug therapy*,  prevention & control
Inhibitory Concentration 50
Injections, Intraperitoneal
Liver / chemistry,  drug effects
Male
Oxonic Acid
Quinic Acid / analogs & derivatives*,  pharmacology,  therapeutic use*
Rats
Rats, Sprague-Dawley
Uric Acid / antagonists & inhibitors*,  blood
Xanthine Oxidase / antagonists & inhibitors,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/4,5-o-dicaffeoylquinic acid methyl ester; 0/Esters; 0/Flavones; 0/potassium oxonate; 315-30-0/Allopurinol; 480-44-4/acacetin; 69-93-2/Uric Acid; 77-95-2/Quinic Acid; 937-13-3/Oxonic Acid; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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