Document Detail


Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child.
MedLine Citation:
PMID:  22877976     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
CONTEXT: Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. OBJECTIVE: The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring. MATERIALS AND METHODS: The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities. RESULTS: 54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.
Authors:
Marta Suárez-Rodríguez; Cristina Azcona-San Julián; Valentín Alzina de Aguilar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-1
Journal Detail:
Title:  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience     Volume:  -     ISSN:  1873-474X     ISO Abbreviation:  Int. J. Dev. Neurosci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8401784     Medline TA:  Int J Dev Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
Affiliation:
AGC Pediatría, Hospital Universitario Central de Asturias, Spain.
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