| Hypothyroxinemia and pregnancy. | |
| | |
MedLine Citation:
|
PMID: 21247845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate the peer-reviewed literature on iodine deficiency and hypothyroxinemia in pregnancy. METHODS: We review published studies on isolated hypothyroxinemia in pregnancy, methodology of free thyroxine (T4) assays, impact of iodine deficiency on free T4 levels, and status of ongoing prospective randomized trials of isolated hypothyroxinemia during pregnancy. RESULTS: Hypothyroxinemia during pregnancy is common. Studies have demonstrated the pivotal role exerted by maternal T4 on fetal brain development and the negative impact of hypothyroxinemia on neurobehavioral performance in offspring. Two intervention studies have demonstrated a positive effect on neurodevelopment in children of mothers promptly supplemented with iodine compared with the neurodevelopment in children of nonsupplemented mothers. Free T4 assays presently in clinical use have limitations. Preliminary results of the Controlled Antenatal Thyroid Study (CATS) are somewhat mixed, and the National Institutes of Health Maternal Fetal Medicine Thyrotropin Study (TSH Study) will be completed in 2015. Knowledge regarding the impact of isolated hypothyroxinemia has progressed, but major questions remain. An optimal diagnostic test for free T4 during pregnancy (accurate, inexpensive, and widely available) remains elusive. Trimester-specific normative data and normal ranges from different geographic regions do not exist. CONCLUSIONS: Data published to date are insufficient to recommend levothyroxine therapy in pregnant women with isolated hypothyroxinemia. Adequate iodine intake should be recommended before conception and early in pregnancy. |
| | |
Authors:
|
Roberto Negro; Offie P Soldin; Maria-Jesus Obregon; Alex Stagnaro-Green |
Related Documents
:
|
23157035 - Effect of uterine artery blood flow on recurrent pregnancy loss. 21268035 - Evaluation of normal fetal atrio-ventricular septum dimensions during pregnancy. 21295395 - Pilot study of comparative placental morphometry in pre-eclamptic and normotensive preg... 21266095 - Maternal fish consumption, fetal growth and the risks of neonatal complications: the ge... 3260435 - 125i-human epidermal growth factor specific binding to placentas and fetal membranes fr... 3699175 - Resectoscopic management of müllerian fusion defects. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 17 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2011 May-Jun |
Date Detail:
|
Created Date: 2011-06-24 Completed Date: 2011-11-08 Revised Date: 2013-04-30 |
Medline Journal Info:
|
Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
|
Languages: eng Pagination: 422-9 Citation Subset: IM |
Affiliation:
|
Division of Endocrinology, V. Fazzi Hospital, 73100, Lecce, Italy. dr.negro@libero.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Chemical Analysis
/
methods Child Female Humans Hypothyroidism / blood, diagnosis, epidemiology, therapy* Iodine / deficiency Pregnancy Pregnancy Complications / blood, epidemiology, therapy* Randomized Controlled Trials as Topic / statistics & numerical data Thyroid Function Tests / methods Thyroxine / blood, deficiency |
| Grant Support | |
ID/Acronym/Agency:
|
R01 AG033867/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7488-70-2/Thyroxine; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cost-effectiveness of parathyroidectomy for primary hyperparathyroidism.
Next Document: Contemporary and practical uses of intraoperative PTH monitoring.