Document Detail

Hypothyroidism and renal function in patients with systolic heart failure.
MedLine Citation:
PMID:  20200629     Owner:  NLM     Status:  MEDLINE    
The extent to which hypothyroidism affects renal function in patients with heart failure remains incompletely explored, despite the known adverse prognostic implications of renal dysfunction in these patients.In a pilot retrospective study, we evaluated 75 patients (age, >or=18 yr) with left ventricular ejection fractions <0.40. Forty-five patients had normal thyroid function (thyroid-stimulating hormone [TSH], 0.35-5.5 micro IU/mL) and 30 had hypothyroidism. The group with hypothyroidism was subdivided into 17 patients who had controlled hypothyroidism (TSH, 0.35-5.5 micro IU/mL) and 13 who had uncontrolled hypothyroidism (TSH, >5.5 micro IU/mL). Renal function, measured in terms of glomerular filtration rate, was analyzed once in each patient, and the populations were statistically compared, with P <0.05 conferring statistical significance.Baseline characteristics in all groups were similar. Mean glomerular filtration rate was better in patients with normal thyroid function than those with hypothyroidism (75.45 +/- 31.48 vs 63.95 +/- 21.43 mL/min/1.73 m2; P=0.032). There was no significant difference between patients with controlled hypothyroidism (66.89 +/- 24.18 mL/min/1.73 m2) and those with normal thyroid function (P=0.131). In patients with uncontrolled hypothyroidism, mean glomerular filtration rate (60.2 +/- 17.4 mL/min/1.73 m2) was significantly worse than in patients with normal thyroid function (P=0.015).We found that heart-failure patients with insufficiently treated hypothyroidism have worse renal function than do patients whose thyroid function is normal or whose hypothyroidism is effectively treated. Larger studies will be needed in order to evaluate this conclusion further. We recommend that hypothyroidism in heart-failure patients be strictly controlled, lest it affect prognosis adversely.
Ramanna Merla; Juan D Martinez; Milagros A Martinez; Wissam Khalife; Susan Bionat; Joanne Bionat; Alejandro Barbagelata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  37     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-05-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  66-9     Citation Subset:  IM    
Department of Internal Medicine, Division of Cardiology, University of Texas Medical Branch, Galveston, Texas 77555, USA.
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MeSH Terms
Biological Markers / blood
Chi-Square Distribution
Creatinine / blood
Glomerular Filtration Rate
Heart Failure, Systolic / blood,  epidemiology*,  physiopathology
Hypothyroidism / blood,  epidemiology*,  physiopathology
Kidney / physiopathology*
Kidney Diseases / blood,  epidemiology*,  physiopathology
Middle Aged
Pilot Projects
Retrospective Studies
Stroke Volume
Thyroid Function Tests
Thyrotropin / blood
Ventricular Function, Left
Reg. No./Substance:
0/Biological Markers; 60-27-5/Creatinine; 9002-71-5/Thyrotropin

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