Document Detail

Hypothyroidism is a predictor of disability pension and loss of labor market income. A Danish register-based study.
MedLine Citation:
PMID:  24915121     Owner:  NLM     Status:  Publisher    
Background: Hypothyroidism is associated with an increased somatic and psychiatric disease burden. Whether there are any socio-economic consequences of hypothyroidism, such as early retirement or loss of income, remains unclarified. Aim: To examine, compared with a matched control group, the risk of receiving disability pension (before the age of 60) and effect on labor market income in patients diagnosed with hypothyroidism. Methods: Observational register-based cohort study. By record-linkage between different Danish health registers, 1745 hypothyroid singletons diagnosed before the age of 60 were each matched with 4 non-hypothyroid controls and followed for a mean of 5 years (range 1-31). Additionally, we included 277 same sex twin pairs discordant for hypothyroidism. The risk of disability pension was evaluated by the Cox regression analysis. Changes in labor market income progress over 5 years were evaluated using a difference in difference model. Results: With a hazard ratio (HR) of 2.24 (95% confidence interval (CI): 1.73-2.89), individuals diagnosed with hypothyroidism had a significantly increased risk of disability pension. This remained significant when adjusting for educational level and comorbidity (HR 1.89; CI: 1.42-2.51). In an analysis of labor market income, two years before compared with two years after the diagnosis of hypothyroidism, the hypothyroid individuals had on average a 1605 € poorer increase than their euthyroid controls (P<0.001). Essentially similar results were found in the twin population. Conclusion: A diagnosis of hypothyroidism, before the age of 60, is associated with loss of labor market income and an 89% increased risk of receiving disability pension.
Marianne Thvilum; Frans Brandt; Thomas Heiberg Brix; Laszlo Hegedüs
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  jc20141407     Citation Subset:  -    
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