| Hypothyroidism enhances carbachol-induced hypothermia in the rat. | |
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MedLine Citation:
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PMID: 2781151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied cholinergic regulation of body temperature in hypothyroid rats. Thyroidectomy caused a progressive decrease in core temperature. Intraventricular injection of carbachol in a dose of 10 nmol did not change core temperature of the normal rat, whereas the same dose of carbachol significantly decreased the temperature of thyroidectomized rats. One hundred nmol carbachol decreased to a greater extent core temperature of the thyroidectomized rats than that of normal rats. Intraventricular injection of atropine significantly increased core temperature of thyroidectomized rats. The present data indicate that brain cholinergic mechanisms participate in controlling temperature in the hypothyroid status and thyroid hormones play a significant role in the brain cholinergic regulation of body temperature. |
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Authors:
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M Mori; M Akuzawa; M Yamaguchi; T Michimata; T Iriuchijima; S Kobayashi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 65 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-10-25 Completed Date: 1989-10-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Gunma University, School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology Body Temperature / drug effects* Carbachol / pharmacology* Hypothyroidism / physiopathology* Male Rats Rats, Inbred Strains Thyroidectomy Time Factors |
| Chemical | |
Reg. No./Substance:
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51-55-8/Atropine; 51-83-2/Carbachol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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