Document Detail

Hypothyroidism after therapy for larynx and pharynx carcinoma.
MedLine Citation:
PMID:  10884190     Owner:  NLM     Status:  MEDLINE    
Early detection of local and regional recurrence is the main goal during follow-up of patients with larynx and pharynx cancer. Hypothyroidism occurring in those patients stays frequently undiagnosed as screening for hypothyroidism is not part of the routine follow-up. This study was performed to assess the prevalence of hypothyroidism in these patients. We included 120 patients (106 male, 14 female) with larynx or pharynx cancer treated more than 2 months earlier (mean = 41 months) in the study. Cancer treatment consisted of either surgery (n = 44), radiotherapy (n = 15), or surgery combined with postoperative radiotherapy (n = 61). In all patients, thyroid function studies (thyrotropin [TSH], free triiodothyronine [FT3], and free thyroxine [FT4]) were performed. Twenty-six of all patients (22%) were hypothyroid; in two patients hypothyroidism was diagnosed postoperatively and these two patients were on replacement therapy with thyroid hormones. The highest rate of hypothyroidism (34%) was present in patients treated with surgery combined with radiotherapy, whereas among patients treated with surgery only 7% were hypothyroid (p < 0.001). There was no difference in the duration of follow-up between therapy and inclusion in the study between those two groups. Two of 15 patients treated only with radiotherapy were diagnosed hypothyroid, but in this group the latency was shorter (p < 0.05). The results indicate that thyroid function studies should be routinely performed in the follow-up of head and neck cancer patients, especially if radiotherapy was part of the treatment.
K Smolarz; G Malke; E Voth; K Scheidhauer; H E Eckel; M Jungehülsing; H Schicha
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  10     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-10-12     Completed Date:  2000-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
Department of Nuclear Medicine, University of Cologne, Germany.
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MeSH Terms
Antineoplastic Agents / therapeutic use
Carcinoma / radiotherapy,  surgery,  therapy*
Combined Modality Therapy
Hypothyroidism / etiology*
Laryngeal Neoplasms / drug therapy,  radiotherapy,  surgery,  therapy*
Middle Aged
Pharyngeal Neoplasms / drug therapy,  radiotherapy,  surgery,  therapy*
Postoperative Complications
Radiation Injuries / complications
Thyroidectomy / methods
Reg. No./Substance:
0/Antineoplastic Agents

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