Document Detail

Hypothetical role of prostaglandins in the onset of preterm labor after fetal surgery.
MedLine Citation:
PMID:  17135752     Owner:  NLM     Status:  MEDLINE    
Preterm labor is one of the most important factors limiting the advancement of fetal surgery programs. While prostaglandins (PGs) have long been indicated as the key factor in the initiation of labor in humans, there is significant evidence showing that the chorionic membrane acts as a powerful barrier between the decidua/myometrium and amniotic PGs during normal pregnancy. After either open or endoscopic fetal surgery the imperfect, non-hermetical closure of the chorion permits leakage of PGs from the amnionic sac, allowing them to reach the decidua and myometrium. The surgical wound in the chorionic barrier could be the major factor involved in preterm labor and delivery after human fetal surgery.
Francesco Pomini; Giuseppe Noia; Salvatore Mancuso
Publication Detail:
Type:  Journal Article; Review     Date:  2006-11-27
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  22     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-16     Completed Date:  2007-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, Rome, Italy.
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MeSH Terms
Amniotic Fluid / metabolism
Chorion / metabolism*,  surgery
Cytokines / metabolism
Fetoscopy / adverse effects*
Fetus / surgery*
Obstetric Labor, Premature / etiology,  metabolism*,  physiopathology
Pregnancy Complications, Infectious / metabolism*,  physiopathology
Prostaglandin-Endoperoxide Synthases / metabolism
Prostaglandins / metabolism*
Uterine Contraction
Reg. No./Substance:
0/Cytokines; 0/Prostaglandins; EC Synthases

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