Document Detail


Hypothetical pathways of cardiac myocyte hypertrophy: response to myocardial injury.
MedLine Citation:
PMID:  8281963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heart is made up of many different cell types, including myocytes, fibroblasts and vascular cells. The cardiac myocyte, although not likely to divide, may respond to gross organ injury by a process of growth or hypertrophy. Cellular hypertrophy, though a normal biological adaptation, has the potential to contribute to the change in the shape and the size of the heart, such as occurs in chronic heart failure. We are now just beginning to understand the signals and early pathways involved in the cardiac myocyte growth response, some of which are reviewed herein.
Authors:
G S Francis; W C Carlyle
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European heart journal     Volume:  14 Suppl J     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-14     Completed Date:  1994-02-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomegaly / physiopathology*
Cell Division
Humans
Hypertrophy
Myocardial Infarction / pathology*,  physiopathology
Myocardium / cytology*
Signal Transduction

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