| Hypothesis: zinc can be effective in treatment of vitiligo. | |
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MedLine Citation:
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PMID: 22121258 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Vitiligo is a common depigmenting skin disorder (prevalence 0.1-2%), still represents a cause of stigmatization and quality of life impairment in a large population. Several theories on vitiligo etiopathogenesis have been suggested including in trauma, stress, and autoimmune and genetic predisposition, accumulation of toxic compounds, altered cellular environment, imbalance in the oxidant-antioxidant system, impaired melanocyte migration and/or proliferation, infection, and psychological factors. Zinc, as a trace element, has many vital functions in human. It is antiapoptotic factor and needed as a cofactor for antioxidant defense system. It plays an important role in the process of melanogenesis. It may be effective in prevention and treatment of vitiligo via some mechanism. Herein, we suggested some probable protective mechanism for zinc in association with vitiligo. |
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Authors:
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Nooshin Bagherani; Reza Yaghoobi; Mohammad Omidian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of dermatology Volume: 56 ISSN: 1998-3611 ISO Abbreviation: Indian J Dermatol Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370750 Medline TA: Indian J Dermatol Country: India |
Other Details:
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Languages: eng Pagination: 480-4 Citation Subset: - |
Affiliation:
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Department of Dermatology, Jundishapour University of Medical Sciences, Ahvaz, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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