| Hypothesis: poly-(R)-3-hydroxybutyrate is a major factor in intraocular pressure. | |
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MedLine Citation:
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PMID: 19410379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short chain poly-(R)-3-hydroxybutyrate (cPHB) is a ubiquitous molecule that readily adheres to others, that is covalently added to proteins and that forms, with polyphosphate, ion channels. High levels of cPHB have been implicated in atherosclerosis and in diabetes. Here, we propose a hypothesis in which cPHB adheres to filaments in the extracellular matrix and this raises intraocular pressure. In a corollary, we propose that a positive feedback relationship between cPHB adherence to filaments, raised IOP and filament stretching constitutes a switch. |
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Authors:
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Vic Norris; Helene Bresson-Dumont; Etienne Gardea; Rosetta N Reusch; Denis Gruber |
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Publication Detail:
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Type: Journal Article Date: 2009-05-01 |
Journal Detail:
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Title: Medical hypotheses Volume: 73 ISSN: 1532-2777 ISO Abbreviation: Med. Hypotheses Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-07-10 Completed Date: 2009-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: United States |
Other Details:
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Languages: eng Pagination: 398-401 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Rouen, Mont Saint Aignan 76821, France. victor.norris@univ-rouen.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cornea
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physiology* Extracellular Matrix / physiology* Humans Hydroxybutyrates / metabolism* Intraocular Pressure / physiology* Models, Biological* Polyesters / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 0/Polyesters; 26063-00-3/poly-beta-hydroxybutyrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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