Document Detail

Hypothesis on the pathogenesis of post-streptococcal glomerulonephritis based on recent clinical and experimental research.
MedLine Citation:
PMID:  2090147     Owner:  NLM     Status:  MEDLINE    
The current theories on the pathogenesis of post streptococcal glomerulonephritis are reviewed. Clinical findings during the last decades have indicated the involvement of an immune mechanism. However, the lack of adequate animal models has hampered a thorough understanding of the development of the disease from the initiating infection to the final glomerulonephritic sequelae. Several facts point to the presence of a special nephritogenic streptococcal factor which is directly or indirectly involved in the pathogenesis. There seems to be a plasminogen activator (PA) with unique properties. Data on animals experiments using streptococci producing this factor as well as on injections of the pure substance are presented and correlated to the finding in post streptococcal glomerulonephritis in man.
S E Holm
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Zentralblatt für Bakteriologie : international journal of medical microbiology     Volume:  274     ISSN:  0934-8840     ISO Abbreviation:  Zentralbl. Bakteriol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-05-31     Completed Date:  1991-05-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203851     Medline TA:  Zentralbl Bakteriol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  325-32     Citation Subset:  IM    
Department of Clinical Bacteriology, University of Umeå, Sweden.
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MeSH Terms
Glomerulonephritis / etiology*
Plasminogen Activators / physiology
Streptococcal Infections / complications*
Reg. No./Substance:
EC 3.4.21.-/Plasminogen Activators

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