| Hypothesis: neonatal necrotizing enterocolitis is caused by the acquisition of a pathogenic organism by a susceptible host infant. | |
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MedLine Citation:
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PMID: 3975856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The following hypothesis is offered for the etiology of neonatal necrotizing enterocolitis (NEC): that NEC is caused by the acquisition of a potentially pathogenic organism by a susceptible host infant. To test this hypothesis, serum IgM, IgG, IgA, C3, and C4, were measured in 11 neonates with NEC and 11 control infants matched for age and birth weight. Mean initial serum IgA was found to be significantly greater (p less than 0.05) in patients with NEC (8.4 mg/dl) than in control subjects (0.6 mg/dl). This difference persisted during a subsequent period of observation. There were no significant differences in initial concentrations of the other immunoglobulins or complement components. Serum IgM was noted to increase and serum IgG to decrease in both study groups during the period of observation. C3 rose minimally and C4 fell in patients with NEC. An explanation for this alteration in serum IgA concentration in infants with NEC is, at this time, speculative. However, this association, suggests that further evaluation of host susceptibility in this patient group may lead to a better understanding of this disorder. |
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Authors:
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M J Bell; P Shackelford; J Molleston |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Surgery Volume: 97 ISSN: 0039-6060 ISO Abbreviation: Surgery Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-09 Completed Date: 1985-04-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 350-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Complement C3
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analysis* Complement C4 / analysis* Disease Susceptibility Enterocolitis, Pseudomembranous / immunology* Humans Immunocompetence Immunoglobulin A / analysis Immunoglobulin G / analysis Immunoglobulin M / analysis Immunoglobulins / analysis* Infant, Newborn |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C4; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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