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Hypothesis of mitochondrial oncogenesis as the trigger of normal cells to cancer cells.
MedLine Citation:
PMID:  24702837     Owner:  NLM     Status:  Publisher    
The Warburg Effect showed that energy metabolism of cancer cells was similar to prokaryotic cells, which were different from normal eucaryotic cells. The Endosymbiotic Theory offered a plausible explanation that the eucaryotic cells were evolved from prokaryotic cells, by which host cells (ancient prokaryotic cells) had ingested mitochondria (ancient aerobic bacteria), which depended on oxidative phosphorylation rather than glycolysis for generating energy. The alteration of energy metabolism might mean that the survival style of cancer cells were the re-evolution from eucaryotic cells to prokaryotic cells. But how this alteration happened was still unknown. This hypothesis tries to explain how mitochondria take part in the re-evolution from normal cell to cancer cell.
Jianping Du
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-18
Journal Detail:
Title:  Medical hypotheses     Volume:  -     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-4-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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