Document Detail


Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia?
MedLine Citation:
PMID:  10638855     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The central nervous system is increasingly being recognised as a target organ for vitamin D via its wide-ranging steroid hormonal effects and via the induction of various proteins such as nerve growth factor. This paper proposes that low maternal vitamin D may impact adversely on the developing foetal brain, leaving the affected offspring at increased risk of adult-onset schizophrenia. The hypothesis can parsimoniously explain diverse epidemiological features of schizophrenia, such as the excess of winter births, increased rates of schizophrenia in dark-skinned migrants to cold climates, the increased rate of schizophrenia births in urban versus rural setting, and the association between prenatal famine and schizophrenia. Studies that will allow rejection of the hypothesis are proposed.
Authors:
J McGrath
Related Documents :
15969755 - Discovery of the photosynthetic relatives of the "maltese mushroom" cynomorium.
12723145 - "rage to order": wallace stevens and hans loewald.
2591915 - Seasonality of births: stability and change in a developing country.
15625205 - Pregnancy, delivery, and neonatal complications in a population cohort of women with sc...
1522425 - Cholelithiasis in infants receiving furosemide: a prospective study of the incidence an...
8470305 - Haemangioma of the vallecula causing acute upper airway obstruction in a 6 1/2 week old...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Schizophrenia research     Volume:  40     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Affiliation:
Queensland Centre for Schizophrenia Research, Wolston Park Hospital and the Department of Psychiatry, University of Queensland, Brisbane, Australia. jjm@brain.wph.uq.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain / embryology
Female
Humans
Infant, Newborn
Pregnancy
Prenatal Exposure Delayed Effects*
Risk Factors
Schizophrenia / etiology*
Vitamin D Deficiency / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An efficient motion estimator with application to medical image registration.
Next Document:  Lateralized brain dysfunction in schizophrenia: a comparison with patients with lateralized structur...