Document Detail

Hypothesis: is low prenatal vitamin D a risk-modifying factor for schizophrenia?
MedLine Citation:
PMID:  10638855     Owner:  NLM     Status:  MEDLINE    
The central nervous system is increasingly being recognised as a target organ for vitamin D via its wide-ranging steroid hormonal effects and via the induction of various proteins such as nerve growth factor. This paper proposes that low maternal vitamin D may impact adversely on the developing foetal brain, leaving the affected offspring at increased risk of adult-onset schizophrenia. The hypothesis can parsimoniously explain diverse epidemiological features of schizophrenia, such as the excess of winter births, increased rates of schizophrenia in dark-skinned migrants to cold climates, the increased rate of schizophrenia births in urban versus rural setting, and the association between prenatal famine and schizophrenia. Studies that will allow rejection of the hypothesis are proposed.
J McGrath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Schizophrenia research     Volume:  40     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-18     Completed Date:  2000-02-18     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Queensland Centre for Schizophrenia Research, Wolston Park Hospital and the Department of Psychiatry, University of Queensland, Brisbane, Australia.
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MeSH Terms
Brain / embryology
Infant, Newborn
Prenatal Exposure Delayed Effects*
Risk Factors
Schizophrenia / etiology*
Vitamin D Deficiency / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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